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perineuriomas

Thursday 28 October 2004

Types

- intraneural perineurioma
- sclerosing perineurioma
- malignant perineurioma

Localixation

- cutaneous perineurioma
- abdominal visceral perineurioma

- soft tissue perineurioma (15958848)

  • abdominal soft tissue perineurioma

Cytogenetics (by subtypes)

- sclerosing perineurioma

  • 46XX,del(10)(q22q24),der(10),del(22)(q11-12q?)/47, idem,+der(10) (sclerosing perineurioma)
  • 46,XY,t(2;10)(p23;q24) (16096405) (sclerosing perineuriomas) (16096405)
    - 47,XX,add(3)(q23),add(6)(q21),-5,-9,-10,-22,+mar1,+mar2,+mars (16096405)

- intraneural perineurioma

  • 45,XX,add(14)(p13),-22,add(22)(q11.2)
  • 46,XX,add(2)(q11.2),add(3)(q12) (16096405)

- abdominal soft tissue perineurioma

Cytogenetics (by cytogenetic anomalies)

- translocations

  • t(2;10)(p23;q24)
  • t(8;9)(q13;q22)

- deletions

  • del(10)(q22q24)
  • del(22)(q11-12q?)

Gene mutations

- somatic mutations or deletions of NF2

References

- Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol. 2005 Sep;29(9):1164-9. PMID: 16096405

- Balarezo FS, Muller RC, Weiss RG, Brown T, Knibbs D, Joshi VV. Soft tissue perineuriomas in children: report of three cases and review of the literature. Pediatr Dev Pathol. 2003 Mar-Apr;6(2):137-41. PMID: 12545405