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laminins

Friday 11 July 2003

Laminins is a group of proteic complex forming the major noncollagenous component of basal membranes. All laminin molecules exist as trimers of alpha, beta and gamma chains that are held in a covalently stabilized coiled coil. Laminins are a major component of basement membranes.

Laminins are the most abundant glycoprotein in the basement membrane and has binding domains for both ECM and cell-surface receptors. In the basal membrane, polymers of laminin and collagen type IV (COL4s) form tightly bound networks. Laminins can also mediate the attachment of cells to connective tissue substrates.

Subtypes

- laminin-1
- laminin-2 (mutations in muscular dystrophy)
- laminin-3
- laminin-4
- laminin-5
- laminin-6
- laminin-7
- laminin-8
- laminin-9
- laminin-10
- laminin-11

Components

laminin alpha chains LAMAs
laminin beta chains LAMBs
laminin gamma chains LAMCs