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Home > A. Molecular pathology > laminins


Friday 11 July 2003

Laminins is a group of proteic complex forming the major noncollagenous component of basal membranes. All laminin molecules exist as trimers of alpha, beta and gamma chains that are held in a covalently stabilized coiled coil. Laminins are a major component of basement membranes.

Laminins are the most abundant glycoprotein in the basement membrane and has binding domains for both ECM and cell-surface receptors. In the basal membrane, polymers of laminin and collagen type IV (COL4s) form tightly bound networks. Laminins can also mediate the attachment of cells to connective tissue substrates.


- laminin-1
- laminin-2 (mutations in muscular dystrophy)
- laminin-3
- laminin-4
- laminin-5
- laminin-6
- laminin-7
- laminin-8
- laminin-9
- laminin-10
- laminin-11


laminin alpha chains LAMAs
laminin beta chains LAMBs
laminin gamma chains LAMCs