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cell-matrix signaling

Friday 11 July 2003

Pathology of cell-extracellular matrix interaction

- mutations of kindlin-1 in Kindler syndrome (kindlin-1 is a human homolog of the Caenorhabditis elegans protein UNC-112 a membrane-associated structural/signaling protein that has been implicated in linking the actin cytoskeleton to the extracellular matrix)

References

- Ffrench-Constant C, Colognato H. Integrins: versatile integrators of extracellular signals. Trends Cell Biol. 2004 Dec;14(12):678-86. PMID: 15564044