- Human pathology

Home > E. Pathology by systems > Locomotory system > Bones > bone-forming tumors

bone-forming tumors

Friday 7 January 2005

bone-forming osseous tumors, osteogenic tumors of bone, osteogenic tumors of bone, osseous lesions of bone; bone-forming tumors of bone; osseous tumors of bone; osteogenic tumors of bones; osteogenic tumors

Digital cases - Digital slides

- osteoid osteoma

- osteoblastoma

- osteosarcomas

Definition: Osteogenic tumours are defined as neoplasms that produce an osteoid or bony matrix.

According to their biological behaviour, they are divided into benign and malignant lesions.

Benign bone-forming neoplasms very rarely undergo malignant transformation. Osteomas are not considered neoplasms and, therefore, are not included in this volume. Osteoid osteomas and osteoblastomas share many clinical and roentgenographical similarities. They cause severe pain which, however, is effectively alleviated by aspirin.

Osteosarcomas are the most frequent bone tumours and are
almost always highly malignant. Most arise in the long bones of
children without a recognizable precursor lesion, but about 15%
arise in adults secondary to a pre-existing condition, such as
Paget disease. Although all osteosarcomas produce osteoid or
bone, they represent different entities based on clinical,
roentgenographic, or histological features. Advances in the clinical
management of osteosarcomas have lead to a significant
increase in 5-year survival rates, which in most centres now
exceed 50%.


- benign bone-forming osseous tumors

  • enostosis (bone island)
  • exostosis
  • osteochondroma
  • osteoma
  • osteoid osteoma (ICD-O:9191/0)
  • osteoblastoma (ICD-O:9200/0)

- malignant bone-forming osseous tumors

  • osteosarcomas (osteogenic sarcomas)
    • conventional intramedullary osteosarcoma
    • telangiectatic osteosarcoma
    • multifocal osteosarcoma
    • intraosseous well-differentiated osteosarcoma
    • intracortical osteosarcoma
    • surface osteosarcoma
      • parosteal osteosarcoma (juxta-cortical osteosarcoma)
      • periosteal osteosarcoma
      • intracortical osteosarcoma
      • high-grade surface osteosarcoma


- bone-forming tumors

  • lamellar bone-forming tumors
  • spongious bone-forming tumors

See also

- tumors of bone