Humpath.com - Human pathology

Home > E. Pathology by systems > Skin > cutaneous squamous cell carcinoma

cutaneous squamous cell carcinoma

Wednesday 26 January 2005

cutaneous epidermoid carcinoma; cutaneous SCC

Digital cases

- UI:94 : Cutaneous squamous cell carcinoma.
- UI:314 : Cutaneous squamous cell carcinoma.
- JRC:10409 : Cutaneous epidermoid carcinoma.

Definition: Cutaneous squamous cell carcinomas (SCC) are the second most commonly diagnosed cancers in fair-skinned people.

Images

- Scalp lesion in old man : sarcomatoid squamous cell carcinoma S100- SOX10- CKAE1/AE3+

Variants

- cutaneous sarcomatoid squamous cell carcinoma

See also

- sarcomatoid carcinomas
- squamous cell carcinoma (SCC)

Allelotyping

- 9p LOH
- 3p LOH
- 9 LOH
- 2q LOH
- 8p LOH
- 13 LOH

Allelic gain

- 3q AG
- 8q AG

-copy number-neutral LOH

- homozygous microdeletion on 9p23 at the protein tyrosine phosphatase receptor type D (PTPRD) locus

References

- Purdie KJ, Lambert SR, Teh MT, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM, Harwood CA, Proby CM, Young BD. Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer. 2007 Jul;46(7):661-9. PMID: 17420988

- Lima-Bessa KM, Menck CF. Skin cancer: lights on genome lesions. Curr Biol. 2005 Jan 26;15(2):R58-61. PMID: 15668158

Portfolio