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CD59

MIM.107271 11p13

Tuesday 8 February 2005

Without adequate protection, the cells of the human body would be susceptible to destruction by the complement system. The main defense against complement lysis is a molecule called protectin (CD59) that is widely distributed in human tissues.

Pathology

- inherited complete deficiency of CD59

References

- Scheinin T, Bohling T, Halme L, Kontiainen S, Bjorge L, Meri S. Decreased expression of protectin (CD59) in gut epithelium in ulcerative colitis and Crohn’s disease. Hum Pathol. 1999 Dec;30(12):1427-30. PMID: 10667419