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necrotizing sarcoid granulomatosis

Monday 7 March 2005

Definition: Necrotizing sarcoid granulomatosis (NSG) is a disorder of unknown etiology, rarely described in childhood, belonging to the heterogeneous group of the pulmonary angiitis and granulomatosis.

One of the characteristics of NSG is to have typically a benign clinical course with minimal treatment with systemic steroids or even with no therapy at all.

Necrotizing sarcoid granulomatosis (NSG) is characterized by pulmonary nodular infiltrates, a typical histology, and a benign clinical course. The etiology and pathogenesis of the disease are still unknown.


- necrotizing granulomas
- non-caseating granulomas
- fibrinoid vasculitis

Differential diagnosis

- systemic granulomatoses

  • Wegener granulomatosis
  • sarcoidosis
  • familial chronic granulomatosis

See also

- Blau syndrome

- pulmonary angiitis and granulomatosis

  • Wegener granulomatosis
  • lymphomatoid granulomatosis
  • necrotizing sarcoid granulomatosis
  • bronchocentric granulomatosis
  • allergic angiitis and granulomatosis (Churg-Strauss syndrome)


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