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Sunday 20 March 2005

The import of proteins into the nucleus proceeds through the nuclear pore complex. Cytoplasmic proteins with a nuclear localization signal (NLS) bind to an importin-alpha/importin-beta heterodimer.

The trimeric complex docks to the cytoplasmic periphery of the nuclear pore complex and is subsequently translocated through as a single entity. The import reaction is terminated by the direct binding of RAN (MIM.601179) to KPNB, which dissociates the importin heterodimer.




- Harel A, Forbes DJ. Importin beta: conducting a much larger cellular symphony. Mol Cell. 2004 Nov 5;16(3):319-30. PMID: 15525506