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parvins

Tuesday 22 March 2005

Definition: The parvins are a family of proteins involved in linking integrins and associated proteins with intracellular pathways that regulate actin cytoskeletal dynamics and cell survival.

Members

PARVA PARVB PARVG

Both alpha-parvin (PARVA) and beta-parvin (PARVB) localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, alpha-actinin and testicular kinase 1.

A complex of PARVA with ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. While PARVA inhibits the activities of Rac1 and testicular kinase 1 and cell spreading, PARVB binds alphaPIX and alpha-actinin, and can promote cell spreading.

In contrast to PARVA, PARVB inhibits ILK activity and reverses some of its oncogenic effects in cancer cells.

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways.

All these proteins have synergistic functions at focal adhesions. These proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion.

References

- Legate KR, Montanez E, Kudlacek O, Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31. PMID: 16493410

- Sepulveda JL, Wu C. The parvins. Cell Mol Life Sci. 2006 Jan;63(1):25-35. PMID: 16314921

- Wu C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim Biophys Acta. 2004 Jul 5;1692(2-3):55-62. PMID: 15246679