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STXs

Sunday 13 July 2003

Syntaxins function in the vesicle fusion process in the presynaptic active zone. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis.

Members

STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX9 STX10
STX11 STX12 STX13 STX14 STX15 STX16 STX17 STX18

- syntaxin-1A (MIM.186590)
- syntaxin-1B (MIM.186590)
- syntaxin-2 (epimorphin) (MIM.132350)
- syntaxin-3 (MIM.600876)
- syntaxin-4 (MIM.186591)
- syntaxin-5 (MIM.603189)
- syntaxin-6 (MIM.603944)
- syntaxin-7 (MIM.603217)
- syntaxin-8 (MIM.604203)
- syntaxin-9 (MIM.)
- syntaxin-10 (MIM.603765)
- syntaxin-11 (MIM.605014)
- syntaxin-12 (MIM.606892) = syntaxin-13 (MIM.606892)
- syntaxin-14 (MIM.)

Pathology

- STX11 germline mutations in familial hemophagocytic lymphohistiocytosis type-4 (FHL4) (15703195)

See also

- syntaxins-containing vesicles
- syntaxins-binding proteins
- insintaxin transport