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MODYs

Friday 15 April 2005

Types

- MODY1 (125850): mutation in the hepatocyte nuclear factor-4-alpha gene (HNF4A) on Ch.20 (MIM.600281)
- MODY2 (MIM.125851): mutation in the glucokinase gene (GCK) (MIM.138079) on Ch.7

References

- Fajans SS, Bell GI, Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med. 2001 Sep 27;345(13):971-80. PMID: 11575290