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EFNs

Wednesday 1 June 2005

Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases (EPHs) in trans on opposing cells.

Members

EFNAs EFNA1 EFNA2 EFNA3 EFNA4 EFNA5
EFNBs EFNB1 EFNB2 EFNB3

Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNAs) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNBs) class, which are transmembrane proteins.

The Eph family of receptors (EPHRs) are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A (EPHAs)and ephrin-B ligands (EPHBs).

Developing nervous system

In the developing nervous system, the Eph-ephrin signaling system controls a large variety of cellular responses including contact-mediated attraction or repulsion, adhesion or de-adhesion, and migration.

Eph-ephrin signaling can be bidirectional, and is subject to modulation by ectodomain cleavage of ephrins and by Eph-ephrin endocytosis.

See also

- EPHs (eprin receptors)

References

- Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 Apr 7; PMID: 17420126

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