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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(11;19)(q21;p13)

t(11;19)(q21;p13)

Friday 9 September 2005

Tumors

- mucoepidermoid carcinoma

- salivary Warthin tumor
- cutaneous clear cell hidradenoma (15729701)

Molecular biology

- TORC1-MAML2 fusion gene by t(11;19)(q21;p13)

  • fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a. MECT1 and WAMTP1) to the Notch coactivator MAML2.

See also

- Oncobase

  • tumoral translocations

References

- t(11;19)(q21;p12p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma. Serra A, Schackert HK, Mohr B, Weise A, Liehr T, Fitze G. J Pediatr Surg. 2007 Jul;42(7):E23-9. PMID: 17618868

- Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)—associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer. 2005 Jun;43(2):202-5. PMID: 15729701

- Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O’Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet. 2003 Feb;33(2):208-13. PMID: 12539049

- El-Naggar AK, Lovell M, Killary AM, Clayman GL, Batsakis JG. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13.1) as the only karyotypic abnormality. Cancer Genet Cytogenet. 1996 Mar;87(1):29-33. PMID: 8646736