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myxofibrosarcoma
Tuesday 11 October 2005
Definition: Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas of elderly patients and has a predilection for the limbs.
Myxofibrosarcoma is the most common sarcoma of elderly patients is treated by complete surgical excision with negative margins.
Frequently elderly, extremities & superficial; progression from low-to-higher grade.
Images
FNA of Myxofibrosarcoma (MFS)
Myxofibrosarcoma (MFS) : Myxofibrosarcoma has characteristic coarse curvilinear blood vessels (arrows) and cytologic atypia.
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- https://twitter.com/TexPathol/status/880404204870938624
Digital slides
JRC:71 : Soft tissue (shoulder): low-grade myxofibrosarcoma .
The term myxofibrosarcoma has been adopted for lesions formerly known as myxoid MFH. These lesions have been moved into the category of fibroblastic tumors.
Myxofibrosarcomas are a distinct and reproducible entity (quite separate from lesions formerly known as pleomorphic MFH), which represent the commonest type of soft tissue sarcoma in older adults.
Myxofibrosarcomas show a particular tendency to arise in subcutaneous tissue of the limbs and show a broad spectrum of morphological grade, but even the high-grade lesions, which may contain non-distinctive pleomorphic areas reminiscent of so-called MFH.
They have a metastatic rate of only approximately 35%, which is lower than most other types of pleomorphic sarcoma.
Variants
epithelioid variant of myxofibrosarcoma (17197925)
low-grade myxofibrosarcoma
Cytogenetics
Highly complex karyotypes with extensive intratumoral heterogeneity have been reported. No consistent aberration.
See also
References
Nascimento AF, Bertoni F, Fletcher CD. Epithelioid Variant of Myxofibrosarcoma: Expanding the Clinicomorphologic Spectrum of Myxofibrosarcoma in a Series of 17 Cases. Am J Surg Pathol. 2007 Jan;31(1):99-105. PMID: 17197925
