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cyclosporine renal toxicity

Monday 24 October 2005

Synopsis

- normal kidney (cyclosporine can cause renal dysfunction by inducing vasoconstriction in the absence of morphological damage)
- thrombotic microangiopathy (arterioles and glomerular tuft)
- chronic glomerular injury

- arteriolar hyalinosis (arteriolar hyalinization)

  • concentric hyalin and medial vacuolization
  • extension into the media

- striped interstitial fibrosis

  • fibrosis extending along medullary rays