- Human pathology

Home > E. Pathology by systems > Digestive system > Cajal cells

Cajal cells

Thursday 3 November 2005

Anomalies of Cajal cells

- loss or absence of interstitial cells of Cajal

- structural anomalies

- Cajal cell hyperplasia

- GIST gastrointestinal stromal tumors


- paraneoplastic dysmotility
- Hirschsprung disease
- hypertrophic pyloric stenosis
- chronic intestinal pseudo-obstruction
- slow transit constipation

Absence or altered distribution of the interstitial cells of Cajal (ICCs) has been described in association with intestinal pseudoobstruction in adults. Abnormalities of the ICCs in intestinal pseudoobstruction should be considered early in the diagnostic workup of children with intestinal pseudoobstruction. (19040916)


- Absence of the interstitial cells of Cajal in a child with chronic pseudoobstruction. Struijs MC, Diamond IR, Pencharz PB, Chang KT, Viero S, Langer JC, Wales PW. J Pediatr Surg. 2008 Dec;43(12):e25-9. PMID: 19040916

- Disorders of interstitial cells of Cajal. Burns AJ. J Pediatr Gastroenterol Nutr. 2007 Dec;45 Suppl 2:S103-6. PMID: 18185068

- Jain D, Moussa K, Tandon M, Culpepper-Morgan J, Proctor DD. Role of interstitial cells of Cajal in motility disorders of the bowel. Am J Gastroenterol. 2003 Mar;98(3):618-24. PMID: 12650797

- Pardi DS, Miller SM, Miller DL, Burgart LJ, Szurszewski JH, Lennon VA, Farrugia G. Paraneoplastic dysmotility: loss of interstitial cells of Cajal. Am J Gastroenterol. 2002 Jul;97(7):1828-33. PMID: 12135044