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GZMB

MIM.123910 14q11.2

Monday 15 September 2003

Cytotoxic granule-associated protein granzyme-B (GZMB) activates caspases and lead to the destruction of virus-infected cells or transformed cells.

Expression in tumors

- angiocentric NK/T-cell lymphoma of the head and neck (60%)

  • all CD56+
  • natural killer (NK) cells and/or activated cytotoxic T cells phenotype

See also

GZMs GZMA GZMB GZMH GZMK GZMM

References

- Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K, Nakamura S. Clinicopathologic and Prognostic Significance of Cytotoxic Molecule Expression in Nodal Peripheral T-Cell Lymphoma, Unspecified. Am J Surg Pathol. 2005 Oct;29(10):1284-1293. PMID: 16160469

- Kim GE, Yang WI, Lee S, Kim YB, Suh CO, Yoon JH, Oh YT, Chung HC, Kim BS. The significance of granzyme B expression in patients with angiocentric lymphoma of the head and neck. Cancer. 2001 Jun 15;91(12):2343-52. PMID: 11413524