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Thursday 19 January 2006

Tight regulation of the contractility of the actomyosin cortex is essential for proper cell locomotion and division.

Enhanced contractility leads, for example, to aberrations in the positioning of the mitotic spindle or to anomalous migration modes that allow tumor cells to escape anti-dissemination treatments.

Spherical membrane protrusions called blebs occasionally appear during cell migration, cell division or apoptosis.


- Paluch E, Sykes C, Prost J, Bornens M. Dynamic modes of the cortical actomyosin gel during cell locomotion and division. Trends Cell Biol. 2006 Jan;16(1):5-10. PMID: 16325405