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lipoproteins

Wednesday 1 February 2006

lipoprotein trait

WP

A lipoprotein is a biochemical assembly that contains both proteins and lipids, bound to the proteins, which allow fats to move through the water inside and outside cells. The proteins serve to emulsify the lipid molecules. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are lipoproteins.

Examples include the plasma lipoprotein particles classified under high-density (HDL) and low-density (LDL) lipoproteins, which enable fats to be carried in the blood stream, the transmembrane proteins of the mitochondrion and the chloroplast, and bacterial lipoproteins.

See also

- intestinal lipoproteins

Open references

- Network-based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits. Sharma A, Gulbahce N, Pevzner SJ, Menche J, Ladenvall C, Folkersen L, Eriksson P, Orho-Melander M, Barab├ísi AL. Mol Cell Proteomics. 2013 Nov;12(11):3398-408. doi : 10.1074/mcp.M112.024851 PMID: 23882023

References

- Wasan KM, Brocks DR, Lee SD, Sachs-Barrable K, Thornton SJ. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat Rev Drug Discov. 2008 Jan;7(1):84-99. PMID: 18079757