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MIM.192225 1p32-p31

Thursday 9 February 2006

Vascular cell adhesion molecule-1, a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of monocytes and lymphocytes.


VCAM1 is a memeber of the Ig superfamily, known to mediate cell adhesion, as:
- NCAM1 (MIM.116930)
- ICAM1 (MIM.147840)
- VCAM1 (vascular cell adhesion molecule-1) (MIM.192225)

Ig superfamily members also mediate antigen recognition:
- immunoglobulins (IGH, IGL, IGK)
- T-cell receptors (TCRA, TCRB, TCRD, TCRG)
- MHC molecules.

In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. PECAM1, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily;

Another subfamily is the carcinoembryonic antigen gene family (CEA gene family).


- In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules.