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sclerosing angiomatoid nodular transformation

Tuesday 4 April 2006

Sclerosing Angiomatoid Nodular Transformation of the Spleen. SANT

Definition: Splenic angiomatoid nodules as altered red pulp tissue entrapped by a nonneoplastic stromal proliferative process.

The characteristic morphologic appearance, immunophenotype, and benign clinical course suggest that this is a distinctive non-neoplastic vascular lesion of the spleen.

Paywall References

- Polyclonality in Sclerosing Angiomatoid Nodular Transformation of the Spleen. Chang KC, Lee JC, Wang YC, Hung LY, Huang Y, Huang WT, Wang RC, Chen TC, Tsai YS, Medeiros LJ. Am J Surg Pathol. 2016 Oct;40(10):1343-51. doi : 10.1097/PAS.0000000000000716
PMID: 27526296

- Martel M, Cheuk W, Lombardi L, Lifschitz-Mercer B, Chan JK, Rosai J. Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion. Am J Surg Pathol. 2004 Oct;28(10):1268-79. PMID: 15371942