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acrorenal malformation association

Thursday 6 April 2006

Limb and urinary tract defects have frequently been reported to occur together as components of a single acrorenal field defect or in many multiple malformation syndromes.

Synopsis

-  urinary malformations (urinary tract anomalies)
- radial ray defects
- micromelia
- amelia

Types

- VACTERL association
- cloacal exstrophy sequence
- caudal regression sequence

Clusters of patients

- micromelia with renal agenesis
- split hand/foot with hydronephrosis
- radial ray anomalies with VACTERL defects
- bilateral limb defects with bilateral renal anomalies

References

- Evans JA, Vitez M, Czeizel A. Patterns of acrorenal malformation associations. Am J Med Genet. 1992 Nov 1;44(4):413-9. PMID: 1442878