Protein family

Articles

• IFTs
  8 November 2011

  Types
  IFT43
  IFT122
  IFT144 (WDR19)

• PRDMs
  16 June 2011

  Members PRDM1 PRDM2 PRDM3 PRDM4 PRDM5 PRDM6 PRDM7 PRDM8 PRDM9 PRDM10 PRDM11 PRDM12 PRDM13 PRDM14 PRDM15 PRDM16
  Pathology
  PRDM1 Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin’s lymphoma. (#21785431#)
  PRDM9 Rare allelic forms of PRDM9 associated with childhood leukemogenesis. (#23222848#)
  PRDM16 PRDM16 is encoding a zinc finger protein with a PR domain that is highly homologous to the MDS1 (MIM.600049)/EVI1 (MIM.165215) (...)

• TRPMs
  16 June 2011

  Members TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8
  References
  Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Chasman DI, Schürks M, Anttila V, de Vries B, Schminke U, Launer LJ, Terwindt GM, van den Maagdenberg AM, Fendrich K, Völzke H, Ernst F, Griffiths LR, Buring JE, Kallela M, Freilinger T, Kubisch C, Ridker PM, Palotie A, Ferrari MD, Hoffmann W, Zee RY, Kurth T. Nat Genet. 2011 Jun 12. PMID: (...)

• STXBs
  29 April 2011

  Members
  STXBP1
  STXBP2
  See also
  STXs (synatxins)

• NALPs
  11 February 2006

  Members NALP1 NALP2 NALP3 NALP4 NALP5 NALP6 NALP7
  NALPs family
  Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) (MIM.608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.
  The long NALP, NALP1 (MIM.606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).
  NALPs are implicated in the activation of proinflammatory caspases (...)

• GSTMs
  5 June 2007

  Glutathione S-transferases (GSTs) are a complex family of multifunctional enzymes thought to play a significant role in cellular detoxification. Cytosolic GSTs have been subdivided into 4 classes: alpha, mu, pi, and theta.
  Four isoenzymes of the mu class (GSTMs) have been identified: GSTM1 (MIM.138350), GSTM2 (MIM.138380), GSTM3 (MIM.138390), and GSTM4 (MIM.138333).

• CHEKs
  14 June 2007

  Members CHEK1 CHEK2
  In the presence of DNA damage or incomplete DNA replication, eukaryotic cells activate cell cycle checkpoints that temporarily halt the cell cycle to permit DNA repair or completion of DNA replication to take place.
  In the presence of extensive damage or absence of timely repair, these checkpoint-signaling pathways may also trigger a pathway that effects programmed cell death or apoptosis.
  DNA damage-activated cell cycle checkpoints are regulated in part by the (...)

• netrins
  23 May 2007

  CHN

• IRAKs
  30 May 2007

  interleukin-1 receptor associated kinases.

• CDC25s
  2 July 2007

  Members: CDC25A, CDC25B, CDC25C
  Functions
  Cell division cycle 25 phosphatases (CDC25s) regulate key transitions between cell cycle phases during normal cell division, and in the event of DNA damage they are key targets of the checkpoint machinery that ensures genetic stability.
  Pathology
  CDC25s proteins overexpression has been reported in a significant number of human cancers.
  References
  Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? (...)

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