Cellular lesions

Articles

• ubiquitin-containing cellular inclusions
  9 January 2006

  Ubiquitin-containing cellular inclusions are characteristic of major neurodegenerative diseases and suggest an involvement of the ubiquitin-proteasome system.
  See also
  Cellular inclusions
  References
  Hol EM, van Leeuwen FW, Fischer DF. The proteasome in Alzheimer’s disease and Parkinson’s disease: lessons from ubiquitin B+1. Trends Mol Med. 2005 Nov;11(11):488-95. PMID: (...)

• Rosenthal fibers
  16 April 2005

  Rosenthal fiber inclusions
  Definition: Subtype of intermediate filament inclusions formed by aggregation of glial fibrillary acidic protein (GFAP ).
  Images
  Incidental, but large pineal cyst. Frequent Rosenthal fibres in cyst wall are typical. https://twitter.com/neuropathobern/status/859447047677779972
  Pathology
  Alexander disease
  pilocytic astrocytoma Image : https://twitter.com/rxmsimages/status/718719835723603968
  pineal (...)

• tumoral juxta-nuclear inclusions
  4 April 2005

  Etiology
  maligant rhabdoid tumor
  infantile digital fibroma (infantile digital fibromatosis)

• neuronal inclusions
  5 January 2005

  Types
  filamentous neuronal inclusions

• esophageal epithelial apoptotic bodies
  25 February 2005

  oesophageal epithelial apoptotic bodies

• pseudo-Gaucher cell
  29 December 2006

  pseudo-Gaucher histiocytes, pseudo-Gaucher macrophages

• lipofuscin deposits
  8 January 2006

  Definition: Lipofuscin pigment granules represent undigested material derived from intracellular lipid peroxidation.
  Images
  Lipofuscin is the "wear-and-tear" pigment of the heart. Morphologically found at the myocytes’ nuclear "poles" https://twitter.com/MelanieBoisMD/status/807701991782842369
  Wikimedia: intestinal melanosis
  Localization
  cardiomyocytic lipofuscin deposits
  hepatocytic lipofuscin deposits
  Kupffer cells lipofuscin deposits
  lipofuscin (...)

• syncitial cells
  18 March 2007

  Digital slides
  JRC:14069 : Lung metastasis of a choriocarcinoma from mediastinum.
  Examples
  normal tissue syncytiotrophoblast
  lesional conditions giant cell transformations of hepatocytes
  syncitial cell tumors choriocarcinoma
  See also
  syncitium

• cytoplasmic globules
  12 March 2007

  Etiology
  in diseases alpha-1-antitrypsine deficiency rete testis hyperplasia with hyaline globule formation (#1702268#)
  in tumors endodermal sinus tumor (yolk sac tumor) infantile digital fibroma vascular tumors malignant rhabdoid tumor (MRT) (#3030922#) eosinophilic intracytoplasmic globules in pulmonary adenocarcinoma(#2476374#)
  Localization
  in hepatocytes alpha-1-antitrypsine deficiency
  See also
  hyaline globules
  matrix globules
  hepatocytic PAS+ non-glycogenic (...)

• cellular ballooning
  18 March 2007

  Example
  hepatocytic ballooning (ballooning hepatocyte, hepatocyte swelling)
  See also
  cellular lesions

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