Translocation-associated tumors

Articles

• TFE3-associated renal cell carcinoma
  18 September 2003

  TFE3 gene fusions associated renal cell carcinoma, pediatric renal cell carcinomas with Xp11.2 rearrangements; Xp11 Translocation Renal Cell Carcinoma (RCC); xp11 translocation renal cell carcinomas
  Definition: The renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children.
  Images
  TFE3-associated renal cell carcinoma
  https://twitter.com/yasminelys/status/800834875699892224 (...)

• colonic Burkitt lymphoma
  11 July 2011

  Digital slides
  UI:1193 : colonic Burkitt lymphoma
  Immunophenotype
  SIg, CD20, CD10 and BCL6 expression. Nearly 100% of cells are Ki-67+.
  Pathogenesis
  Genetic abnormalities: t(8:14) with translocation of the MYC gene. EBV infection is frequent in endemic Burkitt lymphoma and less common in sporadic cases.
  Sporadic Burkitt lymphoma is seen in children and young adults , usually in extranodal sites. Endemic Burkitt lymphoma (Africa) characteristically presents in the jaw. The tumor also (...)

• clear cell sarcoma of the kidney
  14 July 2004, by JA

  CCSK, renal clear cell sarcoma; bone-metastasizing renal tumour of childhood AGCOH PathConsult eMedicine
  Digital slides
  Case 66 (HPC:66) : Clear cell sarcoma of the kidney (CCSK)
  Definition: Clear cell sarcoma of the kidney (CCSK) is a malignant renal tumor of childhood with a propensity to metastasize to bone and other organs. CCSK is linked to internal tandem duplications (ITDs) of the BCOR gene.
  This tumor may also recur many years after its initial diagnosis. The average age (...)

• pleomorphic adenoma
  8 March 2004

  Mixed tumor of salivary glands; salivary pleomorphic adenoma; salivary benign mixed tumor; BMT; pleomorphic adenomas; benign mixed tumor WKPD PO WP
  Definition: Pleomorphic adenoma is a benign neoplastic tumor of the salivary glands. As the name implies, these epithelial tumors are characterized by great histologie diversity; but despite increased cellularity, they are essentially benign lesions.
  Pleomorphic adenoma is the most common type of salivary gland tumor and the most common (...)

• myxoid/round cell liposarcoma
  7 October 2005

  myxoid liposarcoma and round cell liposarcoma group; MRC-LPS
  Definition: Myxoid and round cell liposarcoma accounts for about 30% to 35% of all liposarcomas and, even if still classified by the World Health Organization (WHO) as 2 distinct subtypes, share both clinical and morphologic features.
  See also :
  myxoid liposarcoma
  round cell liposarcoma
  Lesions combining both patterns are frequent and wide agreement exists in considering round cell liposarcoma as the high grade counterpart (...)

• angiomatoid fibrous histiocytoma
  14 October 2003

  Definition: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential and uncertain differentiation.
  Images
  https://twitter.com/JMGardnerMD/status/735824693718974464
  Angiomatoid "malignant" fibrous histiocytoma is considered to be a low-grade sarcoma of childhood, and, with its fibrous pseudocapsule, angiomatoid change, dense lymphoplasmacytic response, and proliferation of spindled or round cells, has been classified as a fibrohistiocytic neoplasm. (...)

• ALK-associated pulmonary adenocarcinoma
  14 June 2011

  ALK-rearranged lung carcinomas, ALK-associated lung cancer
  A subset (1% to 5%) of non-small-cell lung carcinomas harbors the EML4-ALK fusion gene.
  All cases show at least a focal adenocarcinoma component, and rare cases had additional squamous and sarcomatoid differentiation, respectively.
  Solid or acinar growth pattern, cribriform structure, presence of mucous cells (signet-ring cells or goblet cells), abundant extracellular mucus, lack of lepidic growth, and lack of significant nuclear (...)

• myxoid liposarcoma
  1 November 2007

  PO
  Definition: Myxoid liposarcoma displays variably aggressive behavior and responds poorly to available systemic therapies.
  Images
  myxoid liposarcoma https://twitter.com/histiocytosisX/status/748157284644196352 https://twitter.com/a_sleeping_dog/status/773402045911007232 https://twitter.com/JMGardnerMD/status/737075990086590466 https://twitter.com/DanglisFotiosMD/status/734976870110900225 https://twitter.com/solcosao/status/706608037868404736
  FISH FUS rearrangement (...)

• mucoepidermoid carcinoma
  14 June 2006

  pulmonary mucoepidermoid carcinoma; mucoepidermoid carcinoma of the bronchi;
  Digital cases
  HPC:95: pulmonary mucoepidermoid carcinoma.
  JRC:6447 : pulmonary mucoepidermoid carcinoma.
  JRC:19401 : pulmonary mucoepidermoid carcinoma.
  Images
  Mucoepidermoid carcinoma
  https://twitter.com/chioseasi/status/715338200479301633
  https://twitter.com/Helena_Path/status/853996400216035330
  https://twitter.com/bunn_belinda/status/867813656968519680 (...)

• pancreatic solid pseudopapillary tumor
  12 November 2003

  PSPPT; solid-pseudopapillary tumor of the pancreas, Frantz tumor, Frantz’s tumor; solid pseudopapillary tumor of the pancreas; ICD-O codes Solid pseudopapillary neoplasm 8452/1, Solid pseudopapillary carcinoma 8452/3; pancreatic solid pseudopapillary tumor; pancreatic solid and pseudopapillary tumor; Solid-pseudopapillary neoplasm of the pancreas PathConsult
  Definition: Solid pseudopapillary neoplasms of the pancreas are rare pancreatic tumors with mostly benign behavior, affecting (...)

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