Translocation-associated tumors

Articles

• pancreatic solid pseudopapillary tumor
  12 November 2003

  PSPPT; solid-pseudopapillary tumor of the pancreas, Frantz tumor, Frantz’s tumor; solid pseudopapillary tumor of the pancreas; ICD-O codes Solid pseudopapillary neoplasm 8452/1, Solid pseudopapillary carcinoma 8452/3; pancreatic solid pseudopapillary tumor; pancreatic solid and pseudopapillary tumor; Solid-pseudopapillary neoplasm of the pancreas PathConsult
  Definition: Solid pseudopapillary neoplasms of the pancreas are rare pancreatic tumors with mostly benign behavior, affecting (...)

• ALK-associated pulmonary adenocarcinoma
  14 June 2011

  ALK-rearranged lung carcinomas, ALK-associated lung cancer
  A subset (1% to 5%) of non-small-cell lung carcinomas harbors the EML4-ALK fusion gene.
  All cases show at least a focal adenocarcinoma component, and rare cases had additional squamous and sarcomatoid differentiation, respectively.
  Solid or acinar growth pattern, cribriform structure, presence of mucous cells (signet-ring cells or goblet cells), abundant extracellular mucus, lack of lepidic growth, and lack of significant nuclear (...)

• clear cell sarcoma of the kidney
  14 July 2004, by JA

  CCSK, renal clear cell sarcoma; bone-metastasizing renal tumour of childhood AGCOH PathConsult eMedicine
  Digital slides
  Case 66 (HPC:66) : Clear cell sarcoma of the kidney (CCSK)
  Definition: Clear cell sarcoma of the kidney (CCSK) is a malignant renal tumor of childhood with a propensity to metastasize to bone and other organs. CCSK is linked to internal tandem duplications (ITDs) of the BCOR gene.
  This tumor may also recur many years after its initial diagnosis. The average age (...)

• mucoepidermoid carcinoma
  14 June 2006

  pulmonary mucoepidermoid carcinoma; mucoepidermoid carcinoma of the bronchi;
  Digital cases
  HPC:95: pulmonary mucoepidermoid carcinoma.
  JRC:6447 : pulmonary mucoepidermoid carcinoma.
  JRC:19401 : pulmonary mucoepidermoid carcinoma.
  Images
  Mucoepidermoid carcinoma
  https://twitter.com/chioseasi/status/715338200479301633
  https://twitter.com/Helena_Path/status/853996400216035330
  https://twitter.com/bunn_belinda/status/867813656968519680 (...)

• myxoid/round cell liposarcoma
  7 October 2005

  myxoid liposarcoma and round cell liposarcoma group; MRC-LPS
  Definition: Myxoid and round cell liposarcoma accounts for about 30% to 35% of all liposarcomas and, even if still classified by the World Health Organization (WHO) as 2 distinct subtypes, share both clinical and morphologic features.
  See also :
  myxoid liposarcoma
  round cell liposarcoma
  Lesions combining both patterns are frequent and wide agreement exists in considering round cell liposarcoma as the high grade counterpart (...)

• alveolar rhabdomyosarcoma
  25 November 2003

  Images
  Alveolar rhabdomyosarcoma.
  https://twitter.com/histiocytosisX/status/699599913013923840
  https://twitter.com/seattlequinns/status/855202143564742656
  ARMS : focal desmin w/ diffuse myogenin in A-RMS (PCR + PAX3-FOXO1)
  https://twitter.com/histiocytosisX/status/730475540524699649
  Compact ARMS : Alveolar rhabdomyosarcoma may lack alveolar spaces. Solid nodules uniform round cells,fibrous septa. DIFFUSE myogenin.
  https://twitter.com/JMGardnerMD/status/856870953011347456 (...)

• aggressive angiomyxoma
  7 February 2006

  AAMs, ’aggressive’ angiomyxoma; deep aggressive angiomyxoma
  Definition: Aggressive angiomyxoma (AA) is a distinctive, locally aggressive, fibromyxoid tumor of the pelvic and genital soft tissues.
  Digital case
  JRC:1443 : Aggresive angiomyxoma of pelvic soft tissues.
  JRC:14570 : Aggresive angiomyxoma of peritoneum (ischiorectal fossa).
  Images
  Deep (agressive) angiomyxoma. Young women vulvar tumor
  https://twitter.com/luishcruzc/status/758685476341415936 (...)

• colonic Burkitt lymphoma
  11 July 2011

  Digital slides
  UI:1193 : colonic Burkitt lymphoma
  Immunophenotype
  SIg, CD20, CD10 and BCL6 expression. Nearly 100% of cells are Ki-67+.
  Pathogenesis
  Genetic abnormalities: t(8:14) with translocation of the MYC gene. EBV infection is frequent in endemic Burkitt lymphoma and less common in sporadic cases.
  Sporadic Burkitt lymphoma is seen in children and young adults , usually in extranodal sites. Endemic Burkitt lymphoma (Africa) characteristically presents in the jaw. The tumor also (...)

• giant cell angiofibroma
  11 October 2005

  Definition: Giant cell angiofibroma is a phenotypic variant of solitary fibrous tumor (SFT).
  Giant cell angiofibroma seems most often to arise in the head and neck region (predominantly orbit) of adults and which, with the passage of time.
  It may well prove to be a variant of solitary fibrous tumour characterized by prominent multinucleate giant cells and lipofibromatosis.
  It is a rare tumour occurring predominantly in the hands or feet of infants and young children.
  it shows a high (...)

• pleomorphic adenoma
  8 March 2004

  Mixed tumor of salivary glands; salivary pleomorphic adenoma; salivary benign mixed tumor; BMT; pleomorphic adenomas; benign mixed tumor WKPD PO WP
  Definition: Pleomorphic adenoma is a benign neoplastic tumor of the salivary glands. As the name implies, these epithelial tumors are characterized by great histologie diversity; but despite increased cellularity, they are essentially benign lesions.
  Pleomorphic adenoma is the most common type of salivary gland tumor and the most common (...)

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