Translocation-associated tumors

Articles

• clear cell sarcoma of the kidney
  14 July 2004, by JA

  CCSK, renal clear cell sarcoma; bone-metastasizing renal tumour of childhood AGCOH PathConsult eMedicine
  Digital slides
  Case 66 (HPC:66) : Clear cell sarcoma of the kidney (CCSK)
  Definition: Clear cell sarcoma of the kidney (CCSK) is a malignant renal tumor of childhood with a propensity to metastasize to bone and other organs. CCSK is linked to internal tandem duplications (ITDs) of the BCOR gene.
  This tumor may also recur many years after its initial diagnosis. The average age (...)

• lipoblastoma
  7 October 2005

  Fetal Lipoma, Infantile Lipoma, Embryonic Lipoma
  Definition: Lipoblastoma is a rare benign tumor that arises from embryonic adipose tissue and usually occurs in young children. It is a lobulated, localized (lipoblastoma) or diffuse (lipoblastomatosis) tumor, resembling fetal adipose tissue.
  Images
  Lipoblastoma
  https://twitter.com/DrBastaki/status/767703201810374656
  https://twitter.com/kabeerkshah/status/711948424606670849
  https://twitter.com/GSomersPath/status/875061142745436161 (...)

• cellular mesoblastic nephroma
  29 August 2007

  cellular congenital mesoblastic nephroma

• myxoid liposarcoma
  1 November 2007

  PO
  Definition: Myxoid liposarcoma displays variably aggressive behavior and responds poorly to available systemic therapies.
  Images
  myxoid liposarcoma https://twitter.com/histiocytosisX/status/748157284644196352 https://twitter.com/a_sleeping_dog/status/773402045911007232 https://twitter.com/JMGardnerMD/status/737075990086590466 https://twitter.com/DanglisFotiosMD/status/734976870110900225 https://twitter.com/solcosao/status/706608037868404736
  FISH FUS rearrangement (...)

• alveolar rhabdomyosarcoma
  25 November 2003

  Images
  Alveolar rhabdomyosarcoma.
  https://twitter.com/histiocytosisX/status/699599913013923840
  https://twitter.com/seattlequinns/status/855202143564742656
  ARMS : focal desmin w/ diffuse myogenin in A-RMS (PCR + PAX3-FOXO1)
  https://twitter.com/histiocytosisX/status/730475540524699649
  Compact ARMS : Alveolar rhabdomyosarcoma may lack alveolar spaces. Solid nodules uniform round cells,fibrous septa. DIFFUSE myogenin.
  https://twitter.com/JMGardnerMD/status/856870953011347456 (...)

• diffuse type of giant cell tumor of tendon sheath
  18 February 2004

  pigmented villonodular synovitis

• TFE3-associated renal cell carcinoma
  18 September 2003

  TFE3 gene fusions associated renal cell carcinoma, pediatric renal cell carcinomas with Xp11.2 rearrangements; Xp11 Translocation Renal Cell Carcinoma (RCC); xp11 translocation renal cell carcinomas
  Definition: The renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children.
  Images
  TFE3-associated renal cell carcinoma
  https://twitter.com/yasminelys/status/800834875699892224 (...)

• salivary mucoepidermoid carcinoma
  8 March 2004

  salivary gland mucoepidermoid carcinoma PO WKP WP
  Definition: The mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands.
  Mucoepidermoid carcinoma is the most common adult salivary malignancy. It histologically is non-encapsulated and shows three cell types - squamous, mucous and intermediate, and may show prominent oncocytic change. It is associated with t(11;19) fusing MECT1 and MAML2 (MAML2-MECT1 fusion gene).
  Images
  Small (...)

• myxoid chondrosarcoma
  24 August 2004

  Digital case
  JRC:78 : Soft tissue (buttock): Low grade myxoid chondrosarcoma (vs soft tisue myoepithelioma)
  Images
  Myxoid chondrosarcoma
  https://twitter.com/bestpathologist/status/700856118751293440
  Myxoid chondrosarcoma : cytology FNA
  https://twitter.com/SintawatWang/status/844268437929148423
  Microscopy
  Conventional myxoid chondrosarcoma is composed of lobules of uniform spindle cells with limited eosinophilic cytoplasm forming a delicate reticular pattern in a myxoid (...)

• NUTM1-associated midline carcinoma
  5 May 2009

  NUT-associated carcinoma NMC ; NUT midline carcinoma ; Nuclear protein in testis (NUT) midline carcinoma (NMC)
  Definition: NUT midline carcinoma (NMC) is a high-grade malignancy that is defined by rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14.
  Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare and aggressive subset of poorly differentiated squamous cell carcinoma that is defined by t(15,19) and typically presents in the midline structures of (...)

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