Translocation-associated tumors

Articles

• myxoid/round cell liposarcoma
  7 October 2005

  myxoid liposarcoma and round cell liposarcoma group; MRC-LPS
  Definition: Myxoid and round cell liposarcoma accounts for about 30% to 35% of all liposarcomas and, even if still classified by the World Health Organization (WHO) as 2 distinct subtypes, share both clinical and morphologic features.
  See also :
  myxoid liposarcoma
  round cell liposarcoma
  Lesions combining both patterns are frequent and wide agreement exists in considering round cell liposarcoma as the high grade counterpart (...)

• colonic Burkitt lymphoma
  11 July 2011

  Digital slides
  UI:1193 : colonic Burkitt lymphoma
  Immunophenotype
  SIg, CD20, CD10 and BCL6 expression. Nearly 100% of cells are Ki-67+.
  Pathogenesis
  Genetic abnormalities: t(8:14) with translocation of the MYC gene. EBV infection is frequent in endemic Burkitt lymphoma and less common in sporadic cases.
  Sporadic Burkitt lymphoma is seen in children and young adults , usually in extranodal sites. Endemic Burkitt lymphoma (Africa) characteristically presents in the jaw. The tumor also (...)

• clear cell sarcoma of the kidney
  14 July 2004, by JA

  CCSK, renal clear cell sarcoma; bone-metastasizing renal tumour of childhood AGCOH PathConsult eMedicine
  Digital slides
  Case 66 (HPC:66) : Clear cell sarcoma of the kidney (CCSK)
  Definition: Clear cell sarcoma of the kidney (CCSK) is a malignant renal tumor of childhood with a propensity to metastasize to bone and other organs. CCSK is linked to internal tandem duplications (ITDs) of the BCOR gene.
  This tumor may also recur many years after its initial diagnosis. The average age (...)

• myxoid chondrosarcoma
  24 August 2004

  Digital case
  JRC:78 : Soft tissue (buttock): Low grade myxoid chondrosarcoma (vs soft tisue myoepithelioma)
  Images
  Myxoid chondrosarcoma
  https://twitter.com/bestpathologist/status/700856118751293440
  Myxoid chondrosarcoma : cytology FNA
  https://twitter.com/SintawatWang/status/844268437929148423
  Microscopy
  Conventional myxoid chondrosarcoma is composed of lobules of uniform spindle cells with limited eosinophilic cytoplasm forming a delicate reticular pattern in a myxoid (...)

• alveolar rhabdomyosarcoma
  25 November 2003

  Images
  Alveolar rhabdomyosarcoma.
  https://twitter.com/histiocytosisX/status/699599913013923840
  https://twitter.com/seattlequinns/status/855202143564742656
  ARMS : focal desmin w/ diffuse myogenin in A-RMS (PCR + PAX3-FOXO1)
  https://twitter.com/histiocytosisX/status/730475540524699649
  Compact ARMS : Alveolar rhabdomyosarcoma may lack alveolar spaces. Solid nodules uniform round cells,fibrous septa. DIFFUSE myogenin.
  https://twitter.com/JMGardnerMD/status/856870953011347456 (...)

• deep aggressive angiomyxoma
  7 February 2006

  AAMs, ’aggressive’ angiomyxoma

• Ewing sarcoma family of tumors
  2 November 2004

  Primitive neuroectodermal tumor/Ewing sarcoma, PNET/ES, - Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), ES/PNET group tumors, ES/PNET tumors, EFTs, Ewing family of tumors
  Digital cases (Digital slides)
  HPC:31 : Ewing sarcoma
  HPC:132 : Ewing sarcoma
  HPC:182 : Ewing sarcoma
  HPC:376 : EWSR1-FLI1+ bone-forming Ewing sarcoma (EWSR1-FLI1+ small cell osteosarcoma)
  Definition: Ewing sarcoma/peripheral primitive neuro-ectodermal tumor (PNET) is a round-cell sarcoma that may (...)

• diffuse type of giant cell tumor of tendon sheath
  18 February 2004

  pigmented villonodular synovitis

• pancreatic solid pseudopapillary tumor
  12 November 2003

  PSPPT; solid-pseudopapillary tumor of the pancreas, Frantz tumor, Frantz’s tumor; solid pseudopapillary tumor of the pancreas; ICD-O codes Solid pseudopapillary neoplasm 8452/1, Solid pseudopapillary carcinoma 8452/3; pancreatic solid pseudopapillary tumor; pancreatic solid and pseudopapillary tumor; Solid-pseudopapillary neoplasm of the pancreas PathConsult
  Definition: Solid pseudopapillary neoplasms of the pancreas are rare pancreatic tumors with mostly benign behavior, affecting (...)

• ALK/CARS-associated inflammatory myofibroblastic tumor
  3 February 2010

  References
  Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor. Debelenko LV, Arthur DC, Pack SD, Helman LJ, Schrump DS, Tsokos M. Lab Invest. 2003 Sep;83(9):1255-65. PMID: #13679433#

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