Translocation-associated tumors

Articles

• pancreatic solid pseudopapillary tumor
  12 November 2003

  PSPPT; solid-pseudopapillary tumor of the pancreas, Frantz tumor, Frantz’s tumor; solid pseudopapillary tumor of the pancreas; ICD-O codes Solid pseudopapillary neoplasm 8452/1, Solid pseudopapillary carcinoma 8452/3; pancreatic solid pseudopapillary tumor; pancreatic solid and pseudopapillary tumor; Solid-pseudopapillary neoplasm of the pancreas PathConsult
  Definition: Solid pseudopapillary neoplasms of the pancreas are rare pancreatic tumors with mostly benign behavior, affecting (...)

• myxoid/round cell liposarcoma
  7 October 2005

  myxoid liposarcoma and round cell liposarcoma group; MRC-LPS
  Definition: Myxoid and round cell liposarcoma accounts for about 30% to 35% of all liposarcomas and, even if still classified by the World Health Organization (WHO) as 2 distinct subtypes, share both clinical and morphologic features.
  See also :
  myxoid liposarcoma
  round cell liposarcoma
  Lesions combining both patterns are frequent and wide agreement exists in considering round cell liposarcoma as the high grade counterpart (...)

• salivary mucoepidermoid carcinoma
  8 March 2004

  salivary gland mucoepidermoid carcinoma PO WKP WP
  Definition: The mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands.
  Mucoepidermoid carcinoma is the most common adult salivary malignancy. It histologically is non-encapsulated and shows three cell types - squamous, mucous and intermediate, and may show prominent oncocytic change. It is associated with t(11;19) fusing MECT1 and MAML2 (MAML2-MECT1 fusion gene).
  Images
  Small (...)

• clear cell sarcoma of the kidney
  14 July 2004, by JA

  CCSK, renal clear cell sarcoma; bone-metastasizing renal tumour of childhood AGCOH PathConsult eMedicine
  Digital slides
  Case 66 (HPC:66) : Clear cell sarcoma of the kidney (CCSK)
  Definition: Clear cell sarcoma of the kidney (CCSK) is a malignant renal tumor of childhood with a propensity to metastasize to bone and other organs. CCSK is linked to internal tandem duplications (ITDs) of the BCOR gene.
  This tumor may also recur many years after its initial diagnosis. The average age (...)

• lipoblastoma
  7 October 2005

  Fetal Lipoma, Infantile Lipoma, Embryonic Lipoma
  Definition: Lipoblastoma is a rare benign tumor that arises from embryonic adipose tissue and usually occurs in young children. It is a lobulated, localized (lipoblastoma) or diffuse (lipoblastomatosis) tumor, resembling fetal adipose tissue.
  Images
  Lipoblastoma
  https://twitter.com/DrBastaki/status/767703201810374656
  https://twitter.com/kabeerkshah/status/711948424606670849
  https://twitter.com/GSomersPath/status/875061142745436161 (...)

• mucoepidermoid carcinoma
  14 June 2006

  pulmonary mucoepidermoid carcinoma; mucoepidermoid carcinoma of the bronchi;
  Digital cases
  HPC:95: pulmonary mucoepidermoid carcinoma.
  JRC:6447 : pulmonary mucoepidermoid carcinoma.
  JRC:19401 : pulmonary mucoepidermoid carcinoma.
  Images
  Mucoepidermoid carcinoma
  https://twitter.com/chioseasi/status/715338200479301633
  https://twitter.com/Helena_Path/status/853996400216035330
  https://twitter.com/bunn_belinda/status/867813656968519680 (...)

• giant cell fibroblastoma
  25 May 2011

  PO
  Definition: Giant cell fibroblastoma is are childhood fibroblastic tumor of intermediate malignancy with floret-like giant cells and ectatic pseudovascular spaces lined by stromal cells and giant cells.
  Digital cases
  Case 136
  Images
  Giant Cell Fibroblastoma : Giant cells lining pseudovascular spaces t(17;22) as DFSP https://twitter.com/VishwasParekh/status/764099885650042880 (...)

• NUT midline carcinoma
  5 May 2009

  NUT-associated carcinoma NMC
  Definition: NUT midline carcinoma (NMC) is a high-grade malignancy that is defined by rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14.
  NMCs are morphologically indistinguishable from other poorly differentiated carcinomas, and the diagnosis is usually made currently by fluorescence in situ hybridization (FISH).
  Images
  NUT midline carcinoma
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746135/figure/Fig1/ (...)

• myxoid chondrosarcoma
  24 August 2004

  Digital case
  JRC:78 : Soft tissue (buttock): Low grade myxoid chondrosarcoma (vs soft tisue myoepithelioma)
  Images
  Myxoid chondrosarcoma
  https://twitter.com/bestpathologist/status/700856118751293440
  Myxoid chondrosarcoma : cytology FNA
  https://twitter.com/SintawatWang/status/844268437929148423
  Microscopy
  Conventional myxoid chondrosarcoma is composed of lobules of uniform spindle cells with limited eosinophilic cytoplasm forming a delicate reticular pattern in a myxoid (...)

• colonic Burkitt lymphoma
  11 July 2011

  Digital slides
  UI:1193 : colonic Burkitt lymphoma
  Immunophenotype
  SIg, CD20, CD10 and BCL6 expression. Nearly 100% of cells are Ki-67+.
  Pathogenesis
  Genetic abnormalities: t(8:14) with translocation of the MYC gene. EBV infection is frequent in endemic Burkitt lymphoma and less common in sporadic cases.
  Sporadic Burkitt lymphoma is seen in children and young adults , usually in extranodal sites. Endemic Burkitt lymphoma (Africa) characteristically presents in the jaw. The tumor also (...)

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