Translocation-associated tumors

Articles

• salivary mucoepidermoid carcinoma
  8 March 2004

  salivary gland mucoepidermoid carcinoma PO WKP WP
  Definition: The mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands.
  Mucoepidermoid carcinoma is the most common adult salivary malignancy. It histologically is non-encapsulated and shows three cell types - squamous, mucous and intermediate, and may show prominent oncocytic change. It is associated with t(11;19) fusing MECT1 and MAML2 (MAML2-MECT1 fusion gene).
  Images
  Small (...)

• clear cell sarcoma of the kidney
  14 July 2004, by JA

  CCSK, renal clear cell sarcoma; bone-metastasizing renal tumour of childhood AGCOH PathConsult eMedicine
  Digital slides
  Case 66 (HPC:66) : Clear cell sarcoma of the kidney (CCSK)
  Definition: Clear cell sarcoma of the kidney (CCSK) is a malignant renal tumor of childhood with a propensity to metastasize to bone and other organs. CCSK is linked to internal tandem duplications (ITDs) of the BCOR gene.
  This tumor may also recur many years after its initial diagnosis. The average age (...)

• pancreatic solid pseudopapillary tumor
  12 November 2003

  PSPPT; solid-pseudopapillary tumor of the pancreas, Frantz tumor, Frantz’s tumor; solid pseudopapillary tumor of the pancreas; ICD-O codes Solid pseudopapillary neoplasm 8452/1, Solid pseudopapillary carcinoma 8452/3; pancreatic solid pseudopapillary tumor; pancreatic solid and pseudopapillary tumor; Solid-pseudopapillary neoplasm of the pancreas PathConsult
  Definition: Solid pseudopapillary neoplasms of the pancreas are rare pancreatic tumors with mostly benign behavior, affecting (...)

• NUT midline carcinoma
  5 May 2009

  NUT-associated carcinoma NMC
  Definition: NUT midline carcinoma (NMC) is a high-grade malignancy that is defined by rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14.
  NMCs are morphologically indistinguishable from other poorly differentiated carcinomas, and the diagnosis is usually made currently by fluorescence in situ hybridization (FISH).
  Images
  NUT midline carcinoma
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746135/figure/Fig1/ (...)

• myxoid/round cell liposarcoma
  7 October 2005

  myxoid liposarcoma and round cell liposarcoma group; MRC-LPS
  Definition: Myxoid and round cell liposarcoma accounts for about 30% to 35% of all liposarcomas and, even if still classified by the World Health Organization (WHO) as 2 distinct subtypes, share both clinical and morphologic features.
  See also :
  myxoid liposarcoma
  round cell liposarcoma
  Lesions combining both patterns are frequent and wide agreement exists in considering round cell liposarcoma as the high grade counterpart (...)

• TFE3-associated renal cell carcinoma
  18 September 2003

  TFE3 gene fusions associated renal cell carcinoma, pediatric renal cell carcinomas with Xp11.2 rearrangements; Xp11 Translocation Renal Cell Carcinoma (RCC); xp11 translocation renal cell carcinomas
  Definition: The renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children.
  Images
  TFE3-associated renal cell carcinoma
  https://twitter.com/yasminelys/status/800834875699892224 (...)

• mucoepidermoid carcinoma
  14 June 2006

  pulmonary mucoepidermoid carcinoma; mucoepidermoid carcinoma of the bronchi;
  Digital cases
  HPC:95: pulmonary mucoepidermoid carcinoma.
  JRC:6447 : pulmonary mucoepidermoid carcinoma.
  JRC:19401 : pulmonary mucoepidermoid carcinoma.
  Images
  Mucoepidermoid carcinoma
  https://twitter.com/chioseasi/status/715338200479301633
  https://twitter.com/Helena_Path/status/853996400216035330
  https://twitter.com/bunn_belinda/status/867813656968519680 (...)

• alveolar rhabdomyosarcoma
  25 November 2003

  Images
  Alveolar rhabdomyosarcoma.
  https://twitter.com/histiocytosisX/status/699599913013923840
  https://twitter.com/seattlequinns/status/855202143564742656
  ARMS : focal desmin w/ diffuse myogenin in A-RMS (PCR + PAX3-FOXO1)
  https://twitter.com/histiocytosisX/status/730475540524699649
  Compact ARMS : Alveolar rhabdomyosarcoma may lack alveolar spaces. Solid nodules uniform round cells,fibrous septa. DIFFUSE myogenin.
  https://twitter.com/JMGardnerMD/status/856870953011347456 (...)

• lipoblastoma
  7 October 2005

  Fetal Lipoma, Infantile Lipoma, Embryonic Lipoma
  Definition: Lipoblastoma is a rare benign tumor that arises from embryonic adipose tissue and usually occurs in young children. It is a lobulated, localized (lipoblastoma) or diffuse (lipoblastomatosis) tumor, resembling fetal adipose tissue.
  Images
  Lipoblastoma
  https://twitter.com/DrBastaki/status/767703201810374656
  https://twitter.com/kabeerkshah/status/711948424606670849
  https://twitter.com/GSomersPath/status/875061142745436161 (...)

• giant cell angiofibroma
  11 October 2005

  Definition: Giant cell angiofibroma is a phenotypic variant of solitary fibrous tumor (SFT).
  Giant cell angiofibroma seems most often to arise in the head and neck region (predominantly orbit) of adults and which, with the passage of time.
  It may well prove to be a variant of solitary fibrous tumour characterized by prominent multinucleate giant cells and lipofibromatosis.
  It is a rare tumour occurring predominantly in the hands or feet of infants and young children.
  it shows a high (...)

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