Molecular function

Articles

• fatty acid omega oxidation
  25 October 2004

  While the main route of fatty acid metabolism is through beta-oxidation, some minor metabolic pathways such as omega oxidation also contribute to the metabolism of fatty acids and other molecules.
  Omega oxidation occurs in the endoplasmic reticulum rather than the mitochondria, the site of beta-oxidation.
  The omega carbon in a fatty acid is the carbon furthest in the alkyl chain from the carboxylic acid. In the omega oxidation pathway, this carbon is progressively oxidized first to an (...)

• DNA damage
  15 September 2003

  DNA lesions, DNA damages WKP
  Definition: All cells can sustain DNA damage from various sources that are conveniently classified as either endogenous or exogenous in origin.
  See also :
  naturally occurring DNA damage
  DNA damage by reactive oxygen species
  In human cells, both normal metabolic activities and environmental factors such as UV light can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.
  Many of these lesions cause (...)

• RNA regulation
  28 May 2004

  RNA regulons
  Multiple mRNAs are co-regulated by one or more sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability, localization and translation.
  These and other observations have given rise to a model in which mRNAs that encode functionally related proteins are coordinately regulated during cell growth and differentiation as post-transcriptional RNA operons or regulons, through a ribonucleoprotein-driven mechanism.
  References
  Keene JD. RNA regulons: (...)

• nucleotide excision repair
  19 November 2003

  NER pathway, NER system

• base excision repair
  20 November 2003

  Definition: Base excision repair (BER) protects against damage to DNA from reactive oxygen species, methylation, deamination, hydroxylation and other by-products of cellular metabolism.
  The survival of organism depends on the accurate transmission of genetic information from one cell to its daughters. Such faithful transmission requires not only extreme accuracy in replication of DNA and precision in chromosome distribution, but also the ability to survive spontaneous and induced DNA (...)

• gene regulation
  13 July 2003

  Features
  gene regulatory network
  References
  Teichmann SA, Babu MM. Gene regulatory network growth by duplication. Nat Genet. 2004 May;36(5):492-6. Epub 2004 Apr 11. PMID: #15107850#
  Hasty J, McMillen D, Isaacs F, Collins JJ. Computational studies of gene regulatory networks: in numero molecular biology. Nat Rev Genet. 2001 Apr;2(4):268-79. PMID: #11283699#

• mitochondrial protein synthesis
  20 November 2003

  Pathology (mitochondrial protein synthesis disorders)
  Mitochondrial tRNA gene mutations, including heteroplasmic deletions that eliminate one or more tRNAs, as well as point mutations that may be either hetero- or homoplasmic, are associated with a wide spectrum of human diseases.
  sensorineural deafness
  cardiomyopathy
  cardiomyopathy resulting from tRNAIle defects
  MERFF-like disease from tRNALys defects
  Molecular mechanisms associated with these mutations
  loss of translational (...)

• genome integrity
  17 September 2003

  DNa stability, genome stability

• reprogramming
  20 November 2003

  epigenetic reprogramming, nuclear reprogramming, cellular reprogramming
  Types
  epigenetic reprogramming
  nuclear reprogramming
  cellular reprogramming
  Journals
  Cellular Reprogramming (ISSN: 2152-4971 • Bimonthly • Online ISSN: 2152-4998), Mary Ann Liebert, Inc.
  References
  Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, Postovit LM. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer. 2007 Apr;7(4):246-55. PMID: #17384580#
  Hansis (...)

• DNA replication
  20 November 2003

  DNA synthesis; chromosomal replication

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