Molecular function

Articles

• base excision repair
  20 November 2003

  Definition: Base excision repair (BER) protects against damage to DNA from reactive oxygen species, methylation, deamination, hydroxylation and other by-products of cellular metabolism.
  The survival of organism depends on the accurate transmission of genetic information from one cell to its daughters. Such faithful transmission requires not only extreme accuracy in replication of DNA and precision in chromosome distribution, but also the ability to survive spontaneous and induced DNA (...)

• polyubiquitylation
  13 July 2003
• alternative splicing
  13 July 2003

  Alternative splicing (AS) is more a rule than an exception as it affects the expression of 60% of human genes.
  Alternative splicing explains how a vast mammalian proteomic complexity is achieved with a limited number of genes.
  Mutations in AS regulatory sequences are a widespread source of human disease.
  AS regulation not only depends on the interaction of splicing factors with their target sequences in the pre-mRNA but is coupled to transcription.
  A clearer picture is emerging of the (...)

• cell signaling
  13 July 2003

  cellular signalling

• ubiquitination
  13 July 2003

  ubiquitylation

• monoubiquitylation
  13 July 2003

  References
  Salmena L, Pandolfi PP. Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation. Nat Rev Cancer. 2007 Jun;7(6):409-13. PMID: #17508027#

• RNA interference
  13 July 2003

  interfering RNA, RNAi

• RNA regulation
  28 May 2004

  RNA regulons
  Multiple mRNAs are co-regulated by one or more sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability, localization and translation.
  These and other observations have given rise to a model in which mRNAs that encode functionally related proteins are coordinately regulated during cell growth and differentiation as post-transcriptional RNA operons or regulons, through a ribonucleoprotein-driven mechanism.
  References
  Keene JD. RNA regulons: (...)

• molecular signaling
  15 September 2003

  molecular signalling, signal transduction

• protein folding
  13 July 2003

  folded protein

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