Molecular function

Articles

• fatty acid omega oxidation
  25 October 2004

  While the main route of fatty acid metabolism is through beta-oxidation, some minor metabolic pathways such as omega oxidation also contribute to the metabolism of fatty acids and other molecules.
  Omega oxidation occurs in the endoplasmic reticulum rather than the mitochondria, the site of beta-oxidation.
  The omega carbon in a fatty acid is the carbon furthest in the alkyl chain from the carboxylic acid. In the omega oxidation pathway, this carbon is progressively oxidized first to an (...)

• antigen presentation
  7 October 2003

  Actin cytoskeleton
  Following the interaction of antigen-presenting cells (APCs) such as dendritic cells with T cells, the T cell receptor (TCR) signalling pathway leads to early events such as the phosphorylation of the TCR, release of Ca2+, and the recruitment and activation of non-receptor tyrosine kinases and adapter proteins.
  In the context of actin cytoskeleton remodeling, the Arp2/3 complex and Ena/VASP proteins co-localise at the immunological synapse, the structure that is (...)

• nucleoside transport
  9 February 2010

  Plasma membrane transport of nucleosides is mediated by equilibrative and concentrative nucleoside transporters, which may have specificity for purines or pyrimidines.
  Nucleoside transport in mammalian cells is performed by two types of transporters: SLC28s and SLC29s.
  The SLC28s family is responsible for active, sodium-dependent nucleoside transport mainly in specialised cells. In contrast the SLC29s protein family (also known as equilibrative nucleoside transporters) are passive (...)

• DNA damage
  15 September 2003

  DNA lesions, DNA damages WKP
  Definition: All cells can sustain DNA damage from various sources that are conveniently classified as either endogenous or exogenous in origin.
  See also :
  naturally occurring DNA damage
  DNA damage by reactive oxygen species
  In human cells, both normal metabolic activities and environmental factors such as UV light can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.
  Many of these lesions cause (...)

• glycosylation
  6 October 2003

  Definition: Glycosylation is the process or result of addition of saccharides to proteins and lipids. The process is one of four principal co-translational and post-translational modification steps in the synthesis of membrane and secreted proteins and the majority of proteins synthesized in the rough endoplasmic reticulum (RER) undergo glycosylation. It is an enzyme-directed site-specific process, as opposed to the non-ezymatic chemical reaction of glycation.
  There exists N-linked (...)

• oxidative phosphorylation
  30 September 2003

  electron transport system, oxydative phosphorylation, electron transport reaction in mitochondria, OXPHOS system, respiratory chain

• sterol
  7 October 2003

  sterols

• meiotic recombination
  21 November 2003

  meiotic crossover

• telomere maintenance
  29 September 2003

  Two types of telomere maintenance mechanisms (TMMs) have been described in human tumors: telomerase activation and alternative lengthening of telomeres (ALT).
  The vast majority of epithelial tumors rely on telomerase activation. Many mesenchymal tumors rely also on ALT for telomere maintenance.
  Telomeres
  Telomeres, which define the ends of chromosomes, consist of short, tandemly repeated DNA sequences loosely conserved in eukaryotes. Telomerase is a ribonucleoprotein complex ( we only (...)

• gene imprinting
  16 July 2003

  genomic imprinting, parental imprinting

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