Drugs

Articles

• sunitinib
  2 June 2009

  Definition: Sunitinib (marketed as Sutent, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTKs) inhibitor (multiRTKs inhibitors).
  Sunitinib was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006.
  The concept was of a ATP analogue that would compete with ATP for binding to the catalytic site of receptor tyrosine kinases. This concept led (...)

• anaesthetics
  9 May 2005

  References
  Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci. 2004 Sep;5(9):709-20. PMID: #15322529#

• COX inhibitors
  15 April 2005

  Types
  COX-1 inhibitors
  COX-2 inhibitors
  References
  Chan TA. Prostaglandins and the colon cancer connection. Trends Mol Med. 2006 Jun;12(6):240-4. PMID: #16650804#
  Marcus AJ, Broekman MJ, Pinsky DJ. COX inhibitors and thromboregulation. N Engl J Med. 2002 Sep 26;347(13):1025-6. PMID: #12324561#

• 5-FU
  12 March 2004

  5-fluoro-2’-deoxyuridine, 5-fluorouracil, fluorouracil

• ACEIs
  22 November 2004

  angiotensin-converting enzyme inhibitors

• bleomycin
  8 February 2005

  Pathology
  bleomycin-induced pneumopathy
  bleomycin-induced scleroderma
  References
  Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer. 2005 Feb;5(2):102-12. PMID: #15685195#

• halothane
  14 October 2005

  Pathology
  mild form of hepatotoxicity (20%)
  halothane hepatitis halothane-associated massive hepatic necrosis (halothane fulminant hepatitis)

• nucleoside analogues
  27 January 2005

  Nucleoside analogues can cause a mitochondrial myopathy with RRFs in muscle are nucleoside analogues, such as zidovudine, used in the treatment of certain human immunodeficiencies.
  Nucleoside analogues, after conversion into their active form, inhibit mitochondrial DNA polymerase-gamma and induce mtDNA depletion.
  See also
  nucleoside analogues
  mitochondrial diseases
  oxydative phosphorylation (OXPHOS (...)

• amiodarone
  24 February 2005

  Definition: Amiodarone is a potent antiarrhythmic agent.
  Images
  Amiodarone-induced change in thyroid
  https://twitter.com/aakasharmand/status/727148670987149312
  cirrhosis and amiodarone
  https://twitter.com/CArnold_GI/status/735956508492615682
  Liver injury
  Amiodarone causes elevated liver enzymes in up to 30% of patients and steatohepatitis in 1–2% of patients.
  The majority of cases display liver enzyme abnormalities within 24 h of intravenous infusion.
  Even low oral dosing (200 (...)

• NSAIDs
  22 November 2004

  Non-steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory agents (NSAIAs)

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