Drugs

Articles

• platinum
  12 June 2005

  The accidental discovery of the anticancer properties of cisplatin and its clinical introduction in the 1970s represent a major landmark in the history of successful anticancer drugs.
  Although carboplatin—a second-generation analogue that is safer but shows a similar spectrum of activity to cisplatin—was introduced in the 1980s, the pace of further improvements slowed for many years.
  However, in the past several years interest in platinum drugs has increased.
  Key developments include the (...)

• Sulindac
  31 May 2007

  Sulindac is a nonsteroidal anti-inflammatory drug.
  It has been reported to be effective in suppressing tumor growth through the induction of p21WAF1/cip1 in human, animal models of colon cancer and colon cancer cells.
  The efficiency of sulindac in the inhibition of cell proliferation (other than the induction of apoptosis) may be through the suppression of beta-catenin pathway in human breast and lung cancer cell (...)

• methotrexate
  28 November 2005

  MTX

• taxanes
  5 January 2006

  Definition : Taxanes are a class of diterpenes.
  Taxanes were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core.
  Molecules as paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
  Taxanes are important drugs in the treatment of ovarian and other cancers, but their efficacy is limited by intrinsic and acquired drug resistance.
  Resistance (...)

• acetaminophen
  30 January 2006

  Acetaminophen (Tylenol)

• asparginase
  12 March 2006

  Asparaginase is an enzyme that has been purified from E. coli and Erwinia carotovora. It acts by deaminating extracellular L-asparagine, an amino acid that appears to be essential for protein synthesis by some tumour cells lacking adequate levels of asparagine synthetase.
  Asparaginase from Erwinia carotovora is serologically and biochemically distinct from asparaginase from E. coli, although its antineoplastic activity and toxicity is similar. Asparaginase is usually considered to be cell (...)

• artemisinins
  31 May 2006

  Combinations of an artemisinin with other antimalarial drugs are now recommended treatments for Plasmodium falciparum malaria in most endemic areas.
  Several individual molecules have been proposed as targets for artemisinins, in addition to the idea that artemisinins might have many targets at the same time.
  Artemisinins could inhibit the parasite-encoded sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) PfATP6. A polymorphism in the gene encoding PfATP6 is associated with in vitro (...)

• NSAIDs
  22 November 2004

  Non-steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory agents (NSAIAs)

• ACEIs
  22 November 2004

  angiotensin-converting enzyme inhibitors

• bisphosphonate
  6 September 2005

  References
  Rodan GA, Reszka AA. Bisphosphonate mechanism of action. Curr Mol Med. 2002 Sep;2(6):571-7. PMID: #12243249#

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