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Drugs
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methotrexate
28 November 2005 -
amiodarone
24 February 2005Definition: Amiodarone is a potent antiarrhythmic agent.
Images
Amiodarone-induced change in thyroid
https://twitter.com/aakasharmand/status/727148670987149312
cirrhosis and amiodarone
https://twitter.com/CArnold_GI/status/735956508492615682
Liver injury
Amiodarone causes elevated liver enzymes in up to 30% of patients and steatohepatitis in 1–2% of patients.
The majority of cases display liver enzyme abnormalities within 24 h of intravenous infusion.
Even low oral dosing (200 (...) -
alkylating agents
12 March 2006alkylators
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crizotinib
10 June 2010Pfizer drug crizotinibPF-02341066 or 1066, PF-02341066, Xalkori Wikipedia
Molecular target: ALK
Definition: Crizotinib is an ALK inhibitor , ROS1 inhibitor and MET inhibitor .
Crizotinib is undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, advanced non-small cell lung carcinoma (NSCLC ).
Crizotinib is an oral ALK (anaplastic lymphoma kinase) inhibitor under study in patients with advanced NSCLC carrying the echinoderm (...) -
platinum
12 June 2005The accidental discovery of the anticancer properties of cisplatin and its clinical introduction in the 1970s represent a major landmark in the history of successful anticancer drugs.
Although carboplatin—a second-generation analogue that is safer but shows a similar spectrum of activity to cisplatin—was introduced in the 1980s, the pace of further improvements slowed for many years.
However, in the past several years interest in platinum drugs has increased.
Key developments include the (...) -
5-FU
12 March 20045-fluoro-2’-deoxyuridine, 5-fluorouracil, fluorouracil
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HIV integrase inhibitors
12 June 2005References
Ciuffi A, Bushman FD. Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet. 2006 Jul;22(7):388-95. PMID: #16730094#
Pommier Y, Johnson AA, Marchand C. Integrase inhibitors to treat HIV/AIDS. Nat Rev Drug Discov. 2005 Mar;4(3):236-48. PMID: #15729361# -
cyanamide
20 October 2003Microscopical synopsis
pseudo-Lafora bodies in liver (#6307616#) -
bleomycin
8 February 2005Pathology
bleomycin-induced pneumopathy
bleomycin-induced scleroderma
References
Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer. 2005 Feb;5(2):102-12. PMID: #15685195# -
Sulindac
31 May 2007Sulindac is a nonsteroidal anti-inflammatory drug.
It has been reported to be effective in suppressing tumor growth through the induction of p21WAF1/cip1 in human, animal models of colon cancer and colon cancer cells.
The efficiency of sulindac in the inhibition of cell proliferation (other than the induction of apoptosis) may be through the suppression of beta-catenin pathway in human breast and lung cancer cell (...)
