G. Tumoral pathology

lymphomas
15 April 2005

Digital cases (Examples)
HPC:296 : Colonic MALT lymphoma
HPC:302 : Mediastinal-pulmonary diffuse large B-cell lymphoma (DLBCL), EBV-associated
HPC:305 : diffuse large B-cell lymphoma of the tonsil (DLBCL of the tonsil)
WHO classification of lymphomas (2008)
The mature B-cell neoplasms (WHO 2008)
chronic lymphocytic leukemia/small lymphocytic lymphoma
B-cell prolymphocytic leukemia
splenic marginal zone B-cell lymphoma (SMZBCL)
hairy cell leukemia
splenic lymphoma/leukemia, (...)
congenital teratoma
7 April 2005

References
Heerema-McKenney A, Harrison MR, Bratton B, Farrell J, Zaloudek C. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005 Jan;29(1):29-38. PMID: #15613854#
EBV-associated smooth muscle tumors
4 April 2005

Definition: Epstein-Barr virus (EBV)-associated smooth muscle tumors have been reported in young patients with allograft-associated immunosuppression, acquired immunodeficiency syndrome or congenital immunodeficiencies. EBV-associated SMT are frequently multicentric or multifocal and often occur in unusual locations.
Images
https://twitter.com/ArchivesPath/status/748970246275420160
Localization (exemples)
digestive system
liver
spleen
lymph node
brain (#15143769#)
See also (...)
proliferative myositis
29 March 2005

PO
Definition: Infiltrative poorly demarcated intramuscular mass resembling nodular fasciitis but with large basophilic cells resembling ganglion cells.
Histologically almost identical to proliferative fasciitis except located in muscle. It may be related to a reactive process. An occasional history of trauma can be noted.
The proliferative myositis belongs to the "pseudosarcomatous fasciitis and myositis" group, joining nodular fasciitis (NF), proliferative fasciitis (PF), and (...)
histiocyte-rich B-cell lymphoma
21 March 2005

References
Delabie J, Vandenberghe E, Kennes C, Verhoef G, Foschini MP, Stul M, Cassiman JJ, De Wolf-Peeters C. Histiocyte-rich B-cell lymphoma. A distinct clinicopathologic entity possibly related to lymphocyte predominant Hodgkin’s disease, paragranuloma subtype. Am J Surg Pathol. 1992 Jan;16(1):37-48. PMID: #1728195#
verrucous hemangioma
14 March 2005

Definition: The term verrucous hemangioma has been used to describe a congenital vascular anomaly with a progressive verrucous epidermal surface persisting throughout life unless surgically excised.
Verrucous hemangioma are reminiscent of infantile hemangioma with GLUT1 immunopositivity, particularly in its involutive phase. No firm conclusion seems possible as to whether verrucous hemangioma is a malformation or an indolent tumor, but clinical evidence favors the former category. (...)
RICH
14 March 2005
rapidly involuting congenital hemangioma
mesenchymal chondrosarcoma
4 March 2005

Images
mesenchymal chondrosarcoma NGS: cartilage islands w/ background of undifferentiated small round cells; HPC-like vessels.
https://twitter.com/histiocytosisX/status/798903947461361664
https://twitter.com/ARP_Press/status/811371852107051008
Synopsis
mixture of undifferentiated small cells and mature hyaline cartilage islands, positive for vimentin, S-100 and CD99.
Molecular biology
HEY1 and NCOA2 fusion gene : HEY1-NCOA2
Localization
skeletal mesenchymal chondrosarcoma (...)
tumoral cell invasion
28 February 2005
cancer cell invasion
tumoral stroma
28 February 2005

Definition: All tumors, benign and malignant, have two basic components:
(1) proliferating neoplastic cells that constitute their parenchyma
(2) supportive stroma made up of connective tissue and blood vessels.
Although parenchymal cells represent the proliferating "cutting edge" of neoplasms and so determine their behavior and pathologic consequences, the growth and evolution of neoplasms are critically dependent on their stroma. An adequate stromal blood supply is requisite, and the (...)

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G. Tumoral pathology

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