Ageing

• DNA damage theory of aging
  17 October 2019

  WKP
  Definirtion : The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damages. Damage in this context is a DNA alteration that has an abnormal structure. Although both mitochondrial and nuclear DNA damage can contribute to aging, nuclear DNA is the main subject of this analysis. Nuclear DNA damage can contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by increasing cell (...)

• systemic senescence
  24 February 2018

  See also
  senescence cellular senescence tissular senescence systemic senescence : ageing

• tissular senescence
  24 February 2018

  See also
  senescence cellular senescence tissular senescence systemic senescence : ageing

• cellular senescence
  24 February 2018

  See also
  senescence cellular senescence tissular senescence systemic senescence : ageing

• aging
  24 February 2018

  ageing WKP
  Definition: Ageing is the process of becoming older.
  The term refers especially to human beings, many animals, and fungi, whereas for example bacteria, perennial plants and some simple animals are potentially immortal.
  This process can affect any level of organization of living processes or living structures : cells ( cellular senescence ), tissues ( tissular senescence ) or organisms ( systemic senescence or ageing ).
  The senescence is the biological process of ageing. (...)

• ageing-associated diseases
  24 February 2018

  ageing-related diseases; senescence-associated diseases; Aging-associated diseases WKP
  Definition: An aging-associated disease is a disease that is most often seen with increasing frequency with increasing ageing.
  Essentially, aging-associated diseases are complications arising from ageing and senescence.
  Age-associated diseases are to be distinguished from the aging process itself because all adult animals age, save for a few rare exceptions, but not all adult animals experience (...)

• hair graying
  13 April 2016

  Genetics
  IRF4 polymorphisms
  Open references
  Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. Arck PC, Overall R, Spatz K, Liezman C, Handjiski B, Klapp BF, Birch-Machin MA, Peters EM. FASEB J. 2006 Jul;20(9):1567-9. PMID: #16723385# (Free)

• inflammation and ageing
  12 October 2015

  References
  Inflamm-ageing. Cevenini E, Monti D, Franceschi C. Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):14-20. doi:10.1097/MCO.0b013e32835ada13 . PMID: #23132168#

• energy and ageing
  30 September 2015

  Open references
  Energy excess is the main cause of accelerated aging of mammals. Biliński T, Paszkiewicz T, Zadrag-Tecza R. Oncotarget. 2015 May 30;6(15):12909-19. PMID: #26079722# (Free)
  Being cool: how body temperature influences ageing and longevity. Keil G, Cummings E, de Magalhães JP. Biogerontology. 2015 Aug;16(4):383-97. doi:10.1007/s10522-015-9571-2 . PMID: #25832892# (...)

• negligible senescence
  30 September 2015

  Open references
  Stability analysis of a model gene network links aging, stress resistance, and negligible senescence. Kogan V, Molodtsov I, Menshikov LI, Shmookler Reis RJ, Fedichev P. Sci Rep. 2015 Aug 28;5:13589. doi:10.1038/srep13589 . PMID: #26316217# (Free)

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