D. General pathology

• abetalipoproteinemia
  19 June

  Bassen-Kornzweig syndrome WKP
  Abetalipoproteinemia is a rare autosomal recessive disorder that interferes with the normal absorption of fat and fat-soluble vitamins from food.
  It is caused by a mutation in microsomal triglyceride transfer protein resulting in deficiencies in the apolipoproteins B-48 and B-100, which are used in the synthesis and exportation of chylomicrons and VLDL respectively. It is not to be confused with familial dysbetalipoproteinemia.
  Mutations in the (...)

• systemic functions
  14 June

  Organism functions
  Examples
  predation
  vision
  cognition
  locomotion
  digestion
  energy production respiration
  urinary production
  reproduction sexuality
  See also
  functions / function biological functions

• body plan
  6 March

  WKP
  See also : body / organism / animal
  Definition: A body plan is "an assemblage of morphological features shared among many members of a phylum-level group".
  The vertebrate body plan is one of many: invertebrates consist of many phyla.
  This term, usually applied to animals , envisages a "blueprint" encompassing aspects such as symmetry , segmentation and limb disposition.
  Evolutionary developmental biology seeks to explain the origins of diverse body plans.
  Body plans have (...)

• viral-human interactome
  12 October 2015

  Open References
  A viral-human interactome based on structural motif-domain interactions captures the human infectome. Segura-Cabrera A, García-Pérez CA, Guo X, Rodríguez-Pérez MA.
  PLoS One. 2013 Aug 8;8(8):e71526. doi:10.1371/journal.pone.0071526 . eCollection 2013. PMID: #23951184# (Free)

• disease module
  10 October 2015

  disease modularity
  See also
  modularity
  References
  A DIseAse MOdule Detection (DIAMOnD) algorithm derived from a systematic analysis of connectivity patterns of disease proteins in the human interactome. Ghiassian SD, Menche J, Barabási AL. PLoS Comput Biol. 2015 Apr 8;11(4):e1004120. doi:10.1371/journal.pcbi.1004120 . eCollection 2015 Apr. PMID: #25853560#
  Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Menche J, Sharma A, Kitsak M, (...)

• epigenetic biomarkers
  5 January 2014

  Epigenetic marks, such as DNA methylation and histone modifications, comprise part of the epigenetic machinery leading to abnormal gene expression and chromatin instability in disease. Epigenetic changes, particularly in human cancers, are now being considered as novel biological markers for diagnostic and therapeutic utility.
  See also
  epigenetics
  biomarkers

• rheumatoid nodule
  16 June 2011

  rheumatoid nodules
  Definition: Rheumatoid nodule is composed of a core of densely eosinophilic fibrin and necrobiosis surrounded by a chronic inflammatory infiltrate.
  Digital slides
  UI:656 - Rheumatoid nodule.
  JRC:6343 : pulmonary rheumatoid nodule (pulmonary rheumatoid granuloma).
  JRC:6345 : pulmonary rheumatoid nodule (pulmonary rheumatoid granuloma).
  Skin manifestations, including rheumatoid nodules, are relatively common in rheumatoid arthritis.
  These nodules occur in (...)

• heat stroke
  25 March 2009

  Heat stroke is associated with high ambient temperatures and high humidity. Thermoregulatory mechanisms fail, sweating ceases, and core body temperature rises. Body temperatures of 112° to 113°F have been recorded in some terminal cases. Clinically, a rectal temperature of 106°F or higher is considered a grave prognostic sign, and the mortality rate for such patients exceeds 50%.
  The underlying mechanism is marked generalized peripheral vasodilation with peripheral pooling of blood and a (...)

• diet and systemic diseases
  23 March 2009

  The problems of undernutrition and overnutrition, as well as specific nutrient deficiencies, have been discussed; however, the composition of the diet, even in the absence of any of these problems, may make a significant contribution to the causation and progression of a number of diseases. A few examples suffice here.
  Currently one of the most important and controversial issues is the contribution of diet to atherogenesis. The central question is, Can dietary modification prevent or (...)

• blast injury
  23 March 2009

  Blast Injury a violent increase in pressure either in the atmosphere (air blast) or in water (immersion blast). With air blast, the compression wave impinges on the side toward the explosion and so may collapse the thorax or violently compress the abdomen, with rupture of internal organs. The pressure wave may enter the airways and damage the alveoli. The following wave of decreased pressure, with its sudden expansion of the abdomen and thorax, may rupture the intestines or lungs. In (...)

0 | 10 | 20 | 30 | 40 | 50 | 60