A. Molecular pathology

• LAMP2
  7 March

  WKP
  Definition : Lysosome-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins ( LAMPS ).
  The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the (...)

• CTHRC1
  23 February

  WKP
  Definition : Collagen triple helix repeat containing 1 is a protein that in humans is encoded by the CTHRC1 gene.
  The CTHRC1 protein may play a role in the cellular response to arterial injury through involvement in vascular remodeling.
  Pathology
  Collagen triple helix repeat containing 1 (CTHRC1) is overexpressed in different kinds of cancer tissues and may thus promote tumor formation.
  Mutations at this locus have been associated with Barrett esophagus and esophageal (...)

• STRN3
  7 January

  WKP
  Pathology
  NTRK3 fusion genes in fibrosarcomas (#30520818#) NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. CD34-positive fibrosarcoma of bone and soft tissue could be a good candidate for NTRK testing. STRN1-NTRK3 and STRN3-NTRK fusion genes

• lipidome
  29 December 2018

  |WKP|
  Definition : The lipidome refers to the totality of lipids in cells. Lipids are one of the four major molecular components of biological organisms, along with proteins, sugars and nucleic acids.
  Lipidome is a term coined in the context of omics in modern biology, within the field of lipidomics.
  It can be studied using mass spectrometry and bioinformatics as well as traditional lab-based methods.
  The lipidome of a cell can be subdivided into the membrane-lipidome and (...)

• intakes
  29 December 2018

  Types
  lipid intakes
  glucid intakes
  protid intakes

• lipid intakes
  29 December 2018

  Humans have a requirement for certain essential fatty acids, such as linoleic acid (an omega-6 fatty acid) and alpha-linolenic acid (an omega-3 fatty acid) in the diet because they cannot be synthesized from simple precursors in the diet.
  Both of these fatty acids are 18-carbon polyunsaturated fatty acids differing in the number and position of the double bonds.
  Most vegetable oils are rich in linoleic acid (safflower, sunflower, and corn oils).
  Alpha-linolenic acid is found in the green (...)

• TRAF7
  23 November 2018

  Pathology
  adenomatoid tumor of the male and female genital tract is defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. (#29148537#) Free
  Open references
  Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. Mod Pathol. 2018 (...)

• TRAFs
  23 November 2018

  WKP
  Definition : TNF receptor associated factors also known as TRAFs are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.
  Currently, seven TRAF proteins have been characterized in mammals: TRAF1 , TRAF2 , TRAF3 , TRAF4 , TRAF5 , TRAF6 and TRAF7.
  Except for TRAF7 , these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling (...)

• ZBTB46
  23 November 2018

  ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and committed dendritic cell precursors, but not by plasmacytoid dendritic cells, monocytes, macrophages, or other immune cell populations.
  Pathology
  Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin. (#29743654#)
  In a study, all examined cases of Langerhans cell histiocytosis and histiocytic sarcoma (...)

• INSM1
  23 November 2018

  WKP
  Definition: Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.
  Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.
  Pathology
  Merkel cell carcinoma (MCC) is an extremely aggressive skin cancer that must be distinguished from other basaloid cutaneous (...)

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