Definition : Serine/threonine-protein kinase Ds are enzymes that in humans is encoded by the PRKDs genes.
Members of the protein kinase D ( PKDs ) family function in many extracellular receptor-mediated signal transduction pathways.
Pathology
polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes. PMID: #31492931#
The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic (...)
Home > A. Molecular pathology
A. Molecular pathology
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PRKDs
28 October 2020 -
PRKD1
28 October 2020WKP
Definition : Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.
Members of the protein kinase D ( PKDs ) family function in many extracellular receptor-mediated signal transduction pathways.
ThePRKD1 / PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.
Pathology
polymorphous adenocarcinoma of the (...) -
MUC3
28 October 2020( MUC3A and MUC3B ) PO
Synopsis
Upregulated by steroid hormones in vitro
Positive staining: invasive breast carcinoma, gastric carcinoma (associated with poor prognosis)
See also
MUCs -
G-quadruplex
18 August 2020G4 ; G-quadruplex structures WKP
Definition: G-quadruplex (G4) structural motifs have been linked to transcription, replication and genome instability and are implicated in cancer and other diseases. -
kinase fusions
29 April 2020genetic alterations activating MAPK signaling
0.6% of metastati breast cancer harbor fusions (doi:10.1016/j.annonc.2020.04.008. ) Kinase fusions in breast cancers are extremely rare, and appear to be enriched in hormone-resistant, metastatic carcinomas and mutually exclusive with ESR1 mutations. Molecular testing at progression after endocrine therapy should include fusion testing, particularly in the absence of ESR1 hotspot alterations, in an effort to identify additional therapeutic (...) -
RNAs
24 April 2020See also
RNA mRNA -
CpG island hypermethylation
17 April 2020WKP
Definition : CpG island hypermethylation is an epigenetic control aberration that is important for gene inactivation in cancer cells. Hypermethylation of CpG islands has been described in almost every type of tumor.
Many important cellular pathways, such as DNA repair (hMLH1, for example), cell cycle (p14ARF), apoptosis (DAPK), cell adherence (CDH1, CDH13), are inactivated by this epigenetic lesion.
Hypermethylation is linked to methyl-binding proteins, DNA methyltransferases and (...) -
ISM1
16 April 2020isthmin-1 GeneCard UniProt Entrez
Tumoral expression
cutaneous Merckel carcinoma
neuroendocrine tumors -
gaseous signaling molecules
16 April 2020WKP
Definition : Gaseous signaling molecules are gaseous molecules that are either synthesised internally (endogenously) in the organism, tissue or cell or are received by the organism, tissue or cell from outside (say, from the atmosphere or hydrosphere, as in the case of oxygen) and that are used to transmit chemical signals which induce certain physiological or biochemical changes in the organism, tissue or cell.
The term is applied to, for example, oxygen, carbon dioxide, nitric (...) -
HSD3B1
21 February 2020WKP
Definition: HSD3B1 is a human gene that encodes for a 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type I or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1.
While it can carry out the same function as HSD3B2, it localizes primarily to different tissues, such as the placenta and nonsteroidogenic tissues.
Its requirement for the production of progesterone by the placenta, which has a vital role in pregnancy, may be one reason why no (...)
