Contractile proteins in phagocytosis
By applying force to actin filaments, the plasma membrane, and intracellular proteins and organelles, myosins can generate contractility, directly regulate actin assembly to ensure proper phagocytic internalization, and translocate phagosomes or other cargo to appropriate cellular locations. Altering the actomyosin cytoskeleton affects phagocytic behavior.
Paywall references
Squeezing in a Meal: Myosin Functions in Phagocytosis. Barger SR, Gauthier (...)
Home > A. Molecular pathology
A. Molecular pathology
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contractile proteins
9 January 2020 -
PLIN2
14 December 2019WKP
Definition : Adipose differentiation-related protein, also known as perilipin 2 , ADRP or adipophilin, is a protein which belongs from PAT family of cytoplasmic lipid droplet (CLD) binding protein.
In humans it is encoded by the ADFP gene. This protein surrounds the lipid droplet along with phospholipids and are involved in assisting the storage of neutral lipids within the lipid droplets.
Images
adipophilin IHC in sebaceous carcinoma (...) -
FOSs
12 December 2019The Fos gene family ( FOSs ) consists of 4 members: c-Fos , FOSB , FOSL1 , and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
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FOSL1
12 December 2019WKP
The Fos gene family ( FOSs ) consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. -
MAP3K8
12 November 2019Pathology
melanocytic tumors with MAP3K8 fusions https://www.nature.com/articles/s41379-019-0384-8
See also
MAP3Ks -
genetic recombination
11 November 2019WKP
Genetic recombination (also known as genetic reshuffling) is the exchange of genetic material between different organisms which leads to production of offspring with combinations of traits that differ from those found in either parent.
In eukaryotes, genetic recombination during meiosis can lead to a novel set of genetic information that can be passed on from the parents to the offspring. Most recombination is naturally (...) -
mutational signatures
10 November 2019WKP
Examples : ultraviolet mutational signature
Definition : Mutational signatures are characteristic combinations of mutation types arising from specific mutagenesis processes such as DNA replication infidelity, exogenous and endogenous genotoxins exposures, defective DNA repair pathways and DNA enzymatic editing.
Deciphering mutational signatures in cancer provides insight into the biological mechanisms involved in carcinogenesis and normal somatic mutagenesis.
Mutational signatures (...) -
co-amplification
10 November 2019genic co-amplification; gene co-amplification in tumors
Examples
MDM2-CDK4 co-amplification in liposarcomas
TFEB-VEGFA co-amplification in renal cell carcinoma -
PTPRZ1
8 November 2019WKP
Pathology
PTPRZ1-ETV1 fusion in gliomas (#31381204#) -
replication origin
23 September 2019WKP
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008320
https://en.wikipedia.org/wiki/Origin_of_replication