A. Molecular pathology

• MYOCD
  13 July 2003

  myocardin

• SRF
  13 July 2003

  Transcritpion factor regulating immediate-early genes. serum response factor
  Molecular biology
  Recurrent NCOA2 gene rearrangements in congenital/infantile-type spindle cell rhabdomyosarcoma (SRMS) (#23463663#) with SRF with TEAD1
  MYOD1 mutations in adult-type spindle cell rhabdomyosarcoma (SRMS)

• actin microfilaments
  13 July 2003

  actins, actin filament, microfilaments, actin cytoskeleton

• nucleoporins
  13 July 2003

  NUPs

• nuclear pore complexes
  13 July 2003
• DNA repair
  13 July 2003

  DNA reparation, DNA damage response, gene repair

• genomic instability
  13 July 2003

  genetic instability; genome instability
  Definition: Genomic instability is considered as a significant factor in the pathogenesis of cancer.
  There are several patterns of genomic instability, which are reflections of different functional defects in the cancer cells.
  Genomic instability can be divided into 2 categories: Retour ligne manuel
  chromosomal instability (CIN) Retour ligne manuel
  microsatellite instability (MSI).
  Genetic alterations can affect the structure of chromosomes, (...)

• genomic stability
  13 July 2003

  A fundamental axiom of genetic inheritance is a requirement for exceptional genetic stability over many generations of cells and organisms. However, cells have to contend with both intracellular and extracellular environments that constantly challenge the chemical stability of the genome.
  Additionally, although normal metabolic transactions of DNA such as replication, recombination and repair are generally highly accurate, there are limits to the fidelity of these processes, so genomic (...)

• cycle checkpoints
  13 July 2003

  molecular checkpoints

• DNA helicases
  13 July 2003

  helicases

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