A. Molecular pathology

• NONO
  28 January 2017

  WKP
  Definition: Non-POU domain-containing octamer-binding protein (NonO) is a protein that in humans is encoded by the nono gene.
  The NonO protein belongs to the Drosophila behaviour/human splicing (DBHSs ) family of proteins.
  Proteins in the DHBSs family include mammalian SFPQ (splicing factor, proline- and glutamine-rich; a.k.a. PSF), NONO (Non-POU domain-containing octamer-binding protein; a.k.a. p54nrb) and PSPC1 (paraspeckle component 1; a.k.a. PSP1) and invertebrate NONA (Protein (...)

• DNA damage by reactive oxygen species
  27 January 2017

  Free radical damage to DNA, DNA damage by ROS WKP
  See also
  DNA damage naturally occurring DNA damage

• naturally occurring DNA damage
  27 January 2017

  WKP
  See also
  DNA damage DNA damage by reactive oxygen species

• PLK4
  27 January 2017

  WKP
  Definition: Serine/threonine kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. The Drosophila homolog is SAK, the C elegans homolog is zyg-1, and the Xenopus homolog is Plx4.
  PLK4 encodes a member of the polo family of serine/threonine protein kinases / SLKs .
  The protein localizes to centrioles—complex microtubule-based structures found in centrosomes—and regulates centriole duplication during the cell cycle.
  Overexpression of (...)

• VRK2
  27 January 2017

  |WKP|
  Defintion: Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.
  This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.
  This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas.
  Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and (...)

• VRKs
  27 January 2017

  Members : VRK1 and VRK2

• VRK1
  27 January 2017

  WKP
  Definition: Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.
  This gene encodes a member of the vaccinia-related kinase (VRKs ) family of serine/threonine protein kinases.
  This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis , thymus , fetal live r, and carcinomas.
  Its protein localizes to the nucleus and has been shown to promote the stability and nuclear (...)

• BAF
  27 January 2017

  |WKP|
  Definition: In molecular biology, barrier-to-autointegration factor (BAF) is a family of essential proteins that is highly conserved in metazoan evolution, and which may act as DNA-bridging proteins.
  BAF binds directly to double-stranded DNA, to transcription activators, and to inner nuclear membrane proteins, including lamin A filaments that anchor nuclear pore complexes in place, and nuclear LEM-domain proteins that bind to laminin filaments and chromatin.
  BAF has structural (...)

• SESN2
  27 January 2017

  WKP
  This gene SESN2 encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
  The Sestrins constitute a family of evolutionarily-conserved stress-inducible proteins that suppress oxidative stress and regulate adenosine monophosphate-dependent protein kinase (AMPK)- mammalian target of rapamycin (mTOR) signaling.
  By (...)

• NEK2
  27 January 2017

  Definition : Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.
  Interactions
  NEK2 has been shown to interact with MAPK1 and NDC80.
  Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells.
  Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating (...)

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