A. Molecular pathology

• WWC1
  12 January

  KIBRA WKP
  Definition: Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.

• LATS2
  11 January

  WKP
  Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene. It has been associated with the Hippo pathway.
  Functions
  The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated luminal epithelial (...)

• LATS1
  11 January

  WKP
  Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene. It has been associated with the Hippo pathway.
  Functions
  The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated luminal epithelial (...)

• LATSs
  11 January

  Members
  LATS1
  LATS2 WKP
  Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene. It has been associated with the Hippo pathway.
  Functions
  The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of (...)

• DNA repair and neurodegeneration
  9 January

  Paywall References
  DNA repair: A unifying mechanism in neurodegeneration. 2017. doi:10.1038/nature21107.

• PARPs
  9 January

  See :
  PARP1
  PARP2

• ROS DNA damage
  9 January

  See also
  ROS : reactive oxygen species
  DNA damage
  DNA repair

• COL3A1
  6 January

  Pathology
  COL3A1 germline mutations in : Ehlers-Danlos syndrome type III (MIM.130020) COL3A1 : type IV Ehlers-Danlos syndrome (MIM.130050) COL3A1 : aortic aneurysms (MIM.100070) COL3A1 : dissecting aneurysm and generalized fibromuscular dysplasia (MIM.135580)
  IHC use
  Collagen type III α1 is a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast doi:10.1016/j.humpath.2016.07.017.
  See also
  COLs (...)

• CCL21
  6 January

  WKP
  Definition: Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family of chemokines.
  CCL21 chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).
  The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.
  Pathology
  CXCL13 (...)

• ID2
  6 January

  bHLHb26, "cell growth-inhibiting gene 8", GIG8; "inhibitor of differentiation 2", "inhibitor of DNA binding 2, dominant negative helix-loop-helix protein"
  Definition: Inhibitor of DNA binding 2 (Id2), a helix-loop-helix protein of the inhibitor of differentiation (ID) family, is involved in hematopoiesis, mainly through interaction with the E-family of transcription factors.
  Pathology
  Id2 is overexpressed in some types of B-cell lymphomas , including classical Hodgkin lymphoma.
  The (...)

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