A. Molecular pathology

• bHLH-PAS
  20 November 2017

  bHLH-PAS
  See also
  ARNT2

• ARNT2
  20 November 2017

  WKP
  Definition: Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.
  This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors.
  The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli.
  Under (...)

• β-Adrenergic receptor
  29 August 2017

  β-Adrenergic receptor expression in vascular tumors (#22743651#)
  Propranolol has recently emerged as an effective therapy for infantile hemangiomas causing regression.
  The β-adrenergic receptor (AR) antagonist is thought to cause vasoconstriction by its effect on nitric oxide, block angiogenesis by its effect on vascular endothelial growth factor (VEGF), and induce apoptosis.
  The expression of β2-AR (B2-AR) and its phosphorylated form (B2-ARP) have been identified in a case of infantile (...)

• ADAR2
  20 August 2017

  Pathology
  Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis. ADAR2 is overexpressed in EC and that the increase in expression positively correlates with the aggressiveness of the tumor. Furthermore, silencing of ADAR2 in three EC cell lines resulted in a decreased proliferation rate, increased apoptosis, and reduced migration capabilities in vitro. ADAR2 functions as an oncogene in endometrial carcinogenesis and could be a (...)

• NADPH
  8 August 2017

  WKP
  See also : NADH
  Definition: Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
  NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2’ position of the ribose ring that carries the adenine moiety.
  The major source of NADPH in (...)

• SUZ12
  25 July 2017

  WKP
  Images
  LOW-GRADE ENDOMETRIAL STROMAL SARCOMA. NGS: JAZF1-SUZ12. NB: permeation of myometrium; whorls of bland spindle cells; prominent arterioles. https://twitter.com/histiocytosisX/status/888838034518671360

• PDCD1LG2
  19 June 2017

  PD-L2; B7-DC; PDL2 ; CD273 WKP
  PD-L2 (or Programmed cell death 1 ligand 2) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).
  See also
  immune checkpois
  PD-1 and PD-L1
  Links
  http://ecancer.org/news/11795-tumour-pd-l2-expression-may-predict-patient-response-to-anti-pd-1-immunotherapy.php
  Open references
  The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation.
  Bardhan K, (...)

• disease-causing chromosomal regions
  5 May 2017

  Open references
  Fixing the broken system of genetic locus symbols: Parkinson disease and dystonia as examples.
  Marras C, Lohmann K, Lang A, Klein C.
  Neurology. 2012 Mar 27;78(13):1016-24. doi:10.1212/WNL.0b013e31824d58ab.
  PMID: #22454269# Free

• age-associated DNA methylation changes
  5 May 2017

  Open references
  Novel regional age-associated DNA methylation changes within human common disease-associated loci.
  Bell CG, Xia Y, Yuan W, Gao F, Ward K, Roos L, Mangino M, Hysi PG, Bell J, Wang J, Spector TD.
  Genome Biol. 2016 Sep 23;17(1):193.
  PMID: #27663977# Free

• disease-associated changes in DNA methylation
  5 May 2017

  Disease-Associated Changes in DNA Methylation
  Open references
  A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation.
  Rackham OJ, Langley SR, Oates T, Vradi E, Harmston N, Srivastava PK, Behmoaras J, Dellaportas P, Bottolo L, Petretto E.
  Genetics. 2017 Apr;205(4):1443-1458. doi:10.1534/genetics.116.195008.
  PMID: #28213474# (...)

0 | ... | 30 | 40 | 50 | 60 | 70 | 80 | 90 | 100 | 110 | ... | 4280