A. Molecular pathology

• ACTL6A
  12 January

  Definition: Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.
  Interactions
  ACTL6A has been shown to interact with SMARCA2, Myc, Transformation/transcription domain-associated protein, RuvB-like 1 and SMARCA4.
  Pathology
  ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis doi:10.1016/j.ccell.2016.12.001.
  ACTL6A is co-amplified, co-expressed, and physically associated with p63 (...)

• GPRC5A
  12 January

  WKP
  Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.
  Pathology
  GPRC5A is dysregulated in many human cancers and in other diseases.

• WWC1
  12 January

  KIBRA WKP
  Definition: Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.

• LATS2
  11 January

  WKP
  Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene. It has been associated with the Hippo pathway.
  Functions
  The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated luminal epithelial (...)

• LATS1
  11 January

  WKP
  Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene. It has been associated with the Hippo pathway.
  Functions
  The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated luminal epithelial (...)

• LATSs
  11 January

  Members
  LATS1
  LATS2 WKP
  Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene. It has been associated with the Hippo pathway.
  Functions
  The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of (...)

• DNA repair and neurodegeneration
  9 January

  Paywall References
  DNA repair: A unifying mechanism in neurodegeneration. 2017. doi:10.1038/nature21107.

• PARPs
  9 January

  See :
  PARP1
  PARP2

• ROS DNA damage
  9 January

  See also
  ROS : reactive oxygen species
  DNA damage
  DNA repair

• COL3A1
  6 January

  Pathology
  COL3A1 germline mutations in : Ehlers-Danlos syndrome type III (MIM.130020) COL3A1 : type IV Ehlers-Danlos syndrome (MIM.130050) COL3A1 : aortic aneurysms (MIM.100070) COL3A1 : dissecting aneurysm and generalized fibromuscular dysplasia (MIM.135580)
  IHC use
  Collagen type III α1 is a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast doi:10.1016/j.humpath.2016.07.017.
  See also
  COLs (...)

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