translocation-associated immunochemistry
Examples
translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms. 2016. doi:10.1002/cncy.21693. PLAG1 HMGA2 MYB KIT
Home > Technical section > Immunochemistry > IHC techniques
IHC techniques
-
translocation-associated IHC
2 May 2017 -
PD-L1 study
31 October 2016PD-L1 IHC; PD-L1 immunochemistry
Indications
VENTANA PD-L1 assay (SP142 assay) before atezolizumab (TECENTRIQ®) treatment previously treated metastatic non-small cell lung carcinoma (NSCLC ) urothelial carcinoma
non-small cell lung cancer (NSCLC) Predictive PD-L1 immunohistochemistry for non-small cell lung cancer
Antibodies
Ventana SP142
Ventana SP263
Cell signaling E1L3N
Dako 22C3 PharmDx
Dako 28-8 PharmDx (...) -
immunochemistry reactivity
8 August 2016Types
nuclear reactivity
cytoplasmic reactivity cytoplasmic granular reactivity cytoplasmic dot-like reactivity
nuclear and cytoplasmic reactivity
membranous reactivity
See also
immunochemistry -
Immunohistochemical markers
25 February 20153 beta 7 AAD 11A1 14-3-3sigma 15-PGDH 45M1
A A beta 42 abl acid phosphatase ACSM1 actin-general actin-alpha cardiac actin-alpha smooth muscle actin-muscle specific AE1/AE3 (cytokeratin) AF4 AGR2 AKT1 albumin alcian blue ALK alkaline phosphatase ALL1 alpha-1-antichymotrypsin alpha-1-antitrypsin alpha-fetoprotein alpha-lactalbumin AMACR AML1 androgen receptor APC API2-MALT1 Apolipoprotein D arginase1 ATM
B72.3 - bcl1 - bcl2 bcl6 bclXl bcr-abl Beclin1 BerEP4 (...) -
cytoplasmic positivity of TTF-1
22 May 2013cytoplasmic positivity of TTF1 eIHC
Cytoplasmic staining with TTF-1 has been little studied. This cytoplasmic staining is due to a cross-reacting antigen of 160 kd, which is not an alternative splicing product of TTF-115.
In a large series of consecutive cases, about 6% (23/361) of all tumours from a variety of sites showed cytoplasmic staining.
hepatocellular carcinoma
a minority of pulmonary adenocarcinomas show coarse granular cytoplasmic staining
occasionally in squamous (...) -
CA-125
22 May 2013WP PO
CA-125 (cancer antigen 125 or carbohydrate antigen 125) also known as "mucin 16" or "MUC16" is a protein that in humans is encoded by the MUC16 gene.
MUC16 is a member of the mucin family glycoproteins.
CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other benign conditions. -
Anti-Cytokeratin (CAM 5.2)
12 February 2013Anti-Cytokeratin (CAM 5.2) reagent has a primary reactivity with human keratin proteins that correspond to Moll’s peptides #7 and #8, Mr 48 and 52 kilodaltons (kd), respectively.
Cytokeratin 7 and 8 are present on secretory epithelia of normal human tissue but not on stratified squamous epithelium.
Anti-Cytokeratin (CAM 5.2) stains most epithelial-derived tissue, including liver, renal tubular epithelium, and hepatocellular and renal cell carcinomas.
Anti-Cytokeratin (CAM 5.2) might not (...) -
cytokeratin 5/6
26 September 2012Pathology
All squamous carcinomas of the lung express cytokeratin 5/6.
Cytokeratin 5/6 reactivity was observed in all 40 mesotheliomas, but there was none in any of the 30 pulmonary adenocarcinomas.
The cytokeratin 5/6 immunostaining is useful in separating epithelial pleural mesotheliomas from pulmonary adenocarcinomas but also can assist in distinguishing epithelial mesotheliomas from nonpulmonary adenocarcinomas metastatic to the pleura.
Reference
Value of cytokeratin 5/6 (...) -
ProExC
10 August 2012ProExC expression has been shown to perform similarly to p16 as an aid in the diagnosis of cervical dysplasia but has not been well characterized in head and neck squamous cell carcinomas (SCC).
ProExC does not perform well enough to be used as a prognostic marker in oropharyngeal SCC.
References
Evaluation of ProExC as a Prognostic Marker in Oropharyngeal Squamous Cell Carcinomas. Mills AM, Beck AH, Pourmand N, Le QT, Kong CS. Am J Surg Pathol. 2012 Aug;36(8):1158-64. PMID: (...) -
ERG immunochemistry
2 August 2012References
The diagnostic utility of novel immunohistochemical marker ERG in the workup of prostate biopsies with "atypical glands suspicious for cancer". He H, Magi-Galluzzi C, Li J, Carver P, Falzarano S, Smith K, Rubin MA, Zhou M. Am J Surg Pathol. 2011 Apr;35(4):608-14. PMID: #21383613#
ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma. Miettinen M, Wang ZF, Paetau A, Tan SH, Dobi A, Srivastava S, Sesterhenn I. Am J (...)
0 | 10