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DCC

MIM.120470 18q21.3

Friday 2 February 2007

Definition: DCC shows amino acid sequence homology to the neural cell adhesion molecule NCAM (MIM.116930).

Pathology

Deleted in colorectal cancer (DCC) is a candidate tumor-suppressor gene located at chromosome 18q21. However, DCC gene was found to have few somatic mutations and the heterozygous mice (DCC(+/-)) showed a similar frequency of tumor formation compared with the wild-type mice (DCC(+/+)).

DCC is a putative conditional tumor-suppressor gene that is epigenetically inactivated by promoter hypermethylation in a majority of HNSCC. (17018594)

References

- Fearon, E. R.; Cho, K. R.; Nigro, J. M.; Kern, S. E.; Simons, J. W.; Ruppert, J. M.; Hamilton, S. R.; Preisinger, A. C.; Thomas, G.; Kinzler, K. W.; Vogelstein, B. : Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247: 49-56, 1990. PubMed ID : 2294591

- Forcet, C.; Stein, E.; Pays, L.; Corset, V.; Llambi, F.; Tessier-Lavigne, M.; Mehlen, P. : Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417: 443-447, 2002. PubMed ID : 11986622

- Gotley, D. C.; Reeder, J. A.; Fawcett, J.; Walsh, M. D.; Bates, P.; Simmons, D. L.; Antalis, T. M. :The deleted in colon cancer (DCC) gene is consistently expressed in colorectal cancers and metastases. Oncogene 13: 787-795, 1996. PubMed ID : 8761300

- Hohne, M. W.; Halatsch, M.-E.; Kahl, G. F.; Weinel, R. J. :Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res. 52: 2616-2619, 1992. PubMed ID : 1314700

- Jen, J.; Kim, H.; Piantadosi, S.; Liu, Z.-F.; Levitt, R. C.; Sistonen, P.; Kinzler, K. W.; Vogelstein, B.; Hamilton, S. R. : Allelic loss of chromosome 18q and prognosis in colorectal cancer. New Eng. J. Med. 331: 213-221, 1994. PubMed ID : 8015568