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primary cutaneous gamma-deltaT-cell lymphoma

Tuesday 6 December 2016

Primary Cutaneous T-Cell Lymphomas Showing Gamma-Delta (γδ) Phenotype

Primary cutaneous gamma-delta (γδ) T-cell lymphoma is a rare disease that typically involves the dermis and subcutis.

Cases of primary cutaneous T-cell lymphomas can show γδ phenotype and predominantly epidermotropic pattern (EγδTCL).

EγδTCL is a rare presentation of cutaneous T-cell lymphoma that can be distinguished from DSγδTCL based on the extent of epidermotropism and has a better prognosis and longer median survival than DSγδTCL.

However, although EγδTCL resembles mycosis fungoides clinically and histologically, a subset of EγδTCL is more likely to behave more aggressively than typical mycosis fungoides.

Paywall references

- Primary Cutaneous T-Cell Lymphomas Showing Gamma-Delta (γδ) Phenotype and Predominantly Epidermotropic Pattern are Clinicopathologically Distinct From Classic Primary Cutaneous γδ T-Cell Lymphomas. Merrill ED, Agbay R, Miranda RN, Aung PP, Tetzlaff MT, Young KH, Curry JL, Nagarajan P, Ivan D, Prieto VG, Medeiros LJ, Duvic M, Torres-Cabala CA. Am J Surg Pathol. 2016 Nov 22. PMID: 27879514