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immune remodeling

Tuesday 27 February 2007

The term ’immune remodeling’ refers to these phenotypes that are indicative of biological processes of deterioration and repair.

This concept is explored through lessons from studies about the changes in the T-cell repertoire and the functional diversity of otherwise oligoclonal, senescent T cells.

Immune remodeling suggests a gradual process that occurs throughout life. However, similar but more drastic remodeling occurs disproportionately among young patients with chronic disease.

References

- Vallejo AN. Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease. Trends Mol Med. 2007 Jan 30; PMID: 17267287