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pediatric follicular lymphoma

Tuesday 6 March 2007

Follicular lymphoma is a very rare lymphoid malignancy in pediatric patients.

Histologic and immunophenotypic criteria can reliably separate PFL and UFL and that UFL is exceptionally rare in the pediatric age group. PFL associated with particular anatomic sites have distinctive features


- follicular architecture
- grade 2 or 3 histologic features (74%)


- B-cell lineage: CD10+ (80%), CD20+, CD79a+, and BCL-6+
- Bcl-2 (30%)
- CD21 accentuated networks of dendritic reticulum cells within the nodules
- cells negative for BCL-2, p53, and T-cell antigens

Molecular biology

- no t(14;18) detected by polymerase chain reaction


- testis (11260636)


- Follicular lymphomas in children and young adults: a comparison of the pediatric variant with usual follicular lymphoma. Liu Q, Salaverria I, Pittaluga S, Jegalian AG, Xi L, Siebert R, Raffeld M, Hewitt SM, Jaffe ES. Am J Surg Pathol. 2013 Mar;37(3):333-43. doi : 10.1097/PAS.0b013e31826b9b57 PMID: 23108024

- Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, Behm FG. Clinicopathologic analysis of follicular lymphoma occurring in children. Blood. 2002 Mar 15;99(6):1959-64. PMID: 11877266

- Lu D, Medeiros LJ, Eskenazi AE, Abruzzo LV. Primary follicular large cell lymphoma of the testis in a child. Arch Pathol Lab Med. 2001 Apr;125(4):551-4. PMID: 11260636

- Winberg CD, Nathwani BN, Bearman RM, Rappaport H. Follicular (nodular) lymphoma during the first two decades of life: a clinicopathologic study of 12 patients. Cancer. 1981 Nov 15;48(10):2223-35. PMID: 7028244