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Home > A. Molecular pathology > LPP


MIM.600700 3q28

Wednesday 16 May 2007


- LPP-MLL fusion gene in a secondary acute leukemia with a t(3;11)(q28;q23) (11433529)
- LPP-HMGA2 gene fusion by t(3;12)(q27;q14-15)


- Ida CM, Wang X, Erickson-Johnson MR, Wenger DE, Blute ML, Nascimento AG, Oliveira AM. Primary retroperitoneal lipoma: a soft tissue pathology heresy?: report of a case with classic histologic, cytogenetics, and molecular genetic features. Am J Surg Pathol. 2008 Jun;32(6):951-4. PMID: 18551755

- Lemke I, Rogalla P, Grundmann F, Kunze WP, Haupt R, Bullerdiek J. Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas. Cancer Genet Cytogenet. 2002 Oct 15;138(2):160-4. PMID: 12505264

- Lemke I, Rogalla P, Bullerdiek J. A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas. Cytogenet Cell Genet. 2001;95(3-4):153-6. PMID: 12063392

- Daheron, L.; Veinstein, A.; Brizard, F.; Drabkin, H.; Lacotte, L.; Guilhot, F.; Larsen, C. J.; Brizard, A.; Roche, J. : Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11)(q28;q23). Genes Chromosomes Cancer 31: 382-389, 2001. PubMed ID : 11433529

- Tallini G, Dal Cin P, Rhoden KJ, Chiapetta G, Manfioletti G, Giancotti V, Fusco A, Van den Berghe H, Sciot R. Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations. Am J Pathol. 1997 Jul;151(1):37-43. PMID: 9212729

- Petit, M. M. R.; Mols, R.; Schoenmakers, E. F. P. M.; Mandahl, N.; Van de Ven, W. J. M. : LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36: 118-129, 1996. PubMed ID : 8812423

- Schoenmakers, E. P. P. M.; Wanschura, S.; Mols, R.; Bullerdiek, J.; Van den Berghe, H.; Van de Ven, W. J. M. : Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nature Genet. 10: 436-444, 1995. PubMed ID : 7670494

- Dal Cin, P.; Turc-Carel, C.; Sandberg, A. A. : Consistent involvement of band 12q14 in two different translocations in three lipomas from the same patient. Cancer Genet. Cytogenet. 31: 237-240, 1988. PubMed ID : 3349440