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stem cell niches

Wednesday 23 May 2007

Stem cells are rare cells that are uniquely capable of both reproducing themselves (self-renewing) and generating the differentiated cell types that are needed to carry out specialized functions in the body.

Stem cell behaviour, in particular the balance between self-renewal and differentiation, is ultimately controlled by the integration of intrinsic factors with extrinsic cues supplied by the surrounding microenvironment, known as the stem cell niche.

References

- Jones DL, Wagers AJ. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol. 2008 Jan;9(1):11-21. PMID: 18097443

- Scheres B. Stem-cell niches: nursery rhymes across kingdoms. Nat Rev Mol Cell Biol. 2007 May;8(5):345-54. PMID: 17450175