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midfacial necrotizing lesions

Thursday 12 July 2007

The necrotizing lesions of the midfacial mucous membranes can be

- (1) localized or part of a systemic illness
- (2) neoplastic or non-neoplastic
- (3) caused by a specific agent or organism or be seemingly idiopathic;
- (4) self-limited or progressively destructive in varying degrees of severity;
- (5) characterized by a granulomatous or nonspecific tissue reaction with or without vasculitis;
- (6) impossible to classify without clinicopathologic correlation.

Etiology (Examples)

- sarcoidosis
- Wegener granulomatosis
- lymphomatoid granulomatosis

Differential diagnosis

- lethal midline granuloma

References

- Batsakis JG, Luna MA. Midfacial necrotizing lesions. Semin Diagn Pathol. 1987 May;4(2):90-116. PMID: 3313603