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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral chromosomal rearrangements > 1q12-22 rearrangements

1q12-22 rearrangements

Monday 10 September 2007


- 1q12-22 breaks
- dup(1)(q12-21q32)
- trp(1)(q12q32)


- Abnormalities of chromosome arm 1q have frequently been reported in B-cell lymphomas and correlated with poor outcome.

- Five genes mapped to this region (BCL9, MUC1, FCGR2B, IRTA1, and RTA2) have been shown to be deregulated by juxtaposition with the IG genes.

- Other anomalies of the 1q21-22 region are not involved in translocations with the IG genes.

- Unbalanced translocations resulting in trisomy 1q and involving breakpoints at 1q12-21 18% of hepatoblastoma (a malignant embryonal liver tumor that occurs almost exclusively in infants and very young children). (15981236)

See also

- 1q12 region
- Oncobase


- Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21. Tomlinson GE, Douglass EC, Pollock BH, Finegold MJ, Schneider NR. Genes Chromosomes Cancer. 2005 Oct;44(2):177-84. PMID: 15981236

- Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS. Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer. 2002 Dec;35(4):318-28. PMID: 12378526