Humpath.com - Human pathology

Home > A. Molecular pathology > tumor-specific alternative splicing

tumor-specific alternative splicing

Tuesday 18 September 2007

Alternative splicing is the differential processing of exon junctions to produce a new transcript variant from one gene. Some aberrant splicing, however, has been shown to be cancer specific.

Identification of these specific splice variations provide important insight into the molecular mechanism of normal cellular physiology as well as the disease processes.

Presentation

- "RNA expression and splicing profiling from fine-needle samples" by Dr Philippe Viehl, IGR, France at the 2012 Biopathology Symposium.

See also

- alternative splicing
- alternative splicing isoforms
- carcinogenesis
- tumorigenesis
- differential splicing profile

References

- Guimaraes GS, Latini FR, Camacho CP, Maciel RM, Dias-Neto E, Cerutti JM. Identification of candidates for tumor-specific alternative splicing in the thyroid. Genes Chromosomes Cancer. 2006 Jun;45(6):540-53. PMID: 16493598