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t(10;11)(p13-14;q14)

Wednesday 28 November 2007

The t(10;11)(p13-14;q14) is a rare but recurring translocation associated with acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML).

Molecular biology

- PICALM/MLLT10 (CALM/AF10) fusion gene by t(10;11)(p13-14;q14-21) (10554802)

Tumors

The t(10;11)(p13-14;q14-21) is a recurring translocation associated with T-cell acute lymphoblastic leukemia (ALL). This translocation has also been reported in monocytic leukemia or ALL with a very early pre-B phenotype.

- T-cell acute lymphoblastic leukemia (ALL)
- monocytic leukemia
- very early pre-B acute lymphoblastic leukemia (very early pre-B ALL)

References

- Related Articles, LinksNarita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F, Kobayashi H, Nakamura H, Sadamori N, Ohnishi H, Bessho F, Yanagisawa M, Ohki M. Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts. Br J Haematol. 1999 Jun;105(4):928-37. PMID: 10554802

- Kobayashi H, Hosoda F, Maseki N, Sakurai M, Imashuku S, Ohki M, Kaneko Y.Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes.Genes Chromosomes Cancer. 1997 Nov;20(3):253-9. PMID: 9365832 [PubMed - indexed for MEDLINE]