- Human pathology

Home > D. General pathology > Therapy, Toxics and drugs > Nutlin-3A


Friday 29 February 2008

The MDM2-antagonist Nutlin 3A can efficiently induce apoptosis in osteosarcoma cell lines with amplified MDM2. Nutlin-based therapy could be even more important in more common sarcoma types where this aberration is frequent as well- and de-differentiated liposarcomas. Nutlin represents a promising new therapeutic principle for the treatment of an increasing group of sarcomas.


- Müller CR, Paulsen EB, Noordhuis P, Pedeutour F, Saeter G, Myklebost O. Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. Int J Cancer. 2007 Jul 1;121(1):199-205. PMID: 17354236