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Nutlin-3A

Friday 29 February 2008

The MDM2-antagonist Nutlin 3A can efficiently induce apoptosis in osteosarcoma cell lines with amplified MDM2. Nutlin-based therapy could be even more important in more common sarcoma types where this aberration is frequent as well- and de-differentiated liposarcomas. Nutlin represents a promising new therapeutic principle for the treatment of an increasing group of sarcomas.

References

- Müller CR, Paulsen EB, Noordhuis P, Pedeutour F, Saeter G, Myklebost O. Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. Int J Cancer. 2007 Jul 1;121(1):199-205. PMID: 17354236