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intimal sarcoma

Thursday 9 October 2008

intimal sarcoma of heart and great vessels

Images

- Surgical resection of 2 independent primary intimal sarcomas in left atrium (CVP)

- Pulmonary artery intimal sarcoma with MDM2 amplification

Cytogenetics

- 12q13-15 amplification

Molecular biology

- amplification of MDM2 , SAS, and CDK4 , but not of HMGA2, ATF1, or DDIT3 (18036403)

References

- Zhang H, Macdonald WD, Erickson-Johnson M, Wang X, Jenkins RB, Oliveira AM. Cytogenetic and molecular cytogenetic findings of intimal sarcoma. Cancer Genet Cytogenet. 2007 Dec;179(2):146-9. PMID: 18036403