- Human pathology

Home > E. Pathology by systems > Locomotory system > Muscles > skeletal myogenesis

skeletal myogenesis

Wednesday 29 October 2003

The formation of skeletal muscle is a multistep process orchestrated by the basic helix-loop-helix myogenic regulatory factors (MRFs).

A wide array of proteins can interact with the MRFs, resulting in either induction or repression of their myogenic potential and subsequent MRF-mediated muscle-specific transcription.

Findings published over the past few years have unambiguously established a key role for the p38 MAP kinase pathway in the control of muscle gene expression at different stages of the myogenic process.

Pathology of myogenesis


- Palacios D, Puri PL. The epigenetic network regulating muscle development and regeneration. J Cell Physiol. 2006 Apr;207(1):1-11. PMID: 16155926

- Berkes CA, Tapscott SJ. MyoD and the transcriptional control of myogenesis. Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):585-95. PMID: 16099183

- Sartorelli V, Caretti G. Mechanisms underlying the transcriptional regulation of skeletal myogenesis. Curr Opin Genet Dev. 2005 Oct;15(5):528-35. PMID: 16055324

- Dhawan J, Rando TA. Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment. Trends Cell Biol. 2005 Dec;15(12):666-73. PMID: 16243526

- Lluis F, Perdiguero E, Nebreda AR, Munoz-Canoves P. Regulation of skeletal muscle gene expression by p38 MAP kinases. Trends Cell Biol. 2006 Jan;16(1):36-44. PMID: 16325404

- Parker MH, Seale P, Rudnicki MA. Looking back to the embryo: defining transcriptional networks in adult myogenesis. Nat Rev Genet. 2003 Jul;4(7):497-507. PMID: 12838342

- Arber S, Burden SJ, Harris AJ. Patterning of skeletal muscle. Curr Opin Neurobiol. 2002 Feb;12(1):100-3. PMID: 11861171